Circulating antibodies to α-enolase and phospholipase A2 receptor and composition of glomerular deposits in Japanese patients with primary or secondary membranous nephropathy

Clinical and Experimental Nephrology
Yukihiro KimuraHirokazu Imai

Abstract

Phospholipase A2 receptor (PLA2R) is recognized as a target antigen in primary membranous nephropathy (MN); Anti-α-enolase antibody in primary and secondary MN has been proposed, however, little is known about the potential contribution of α-enolase to the pathogenesis of MN. We evaluated circulating antibodies to α-enolase by a dot blotting system and PLA2R by indirect immunofluorescence, and glomerular deposition of these proteins in 25 patients with primary MN, 20 patients with secondary MN, 44 patients with collagen disease or severe infection, 60 patients with nephritis (each ten patients of IgA nephropathy, focal segmental gloemrulosclerosis, minimal change nephrotic syndrome, membranoproliferative glomeurlonephritis, diabetic glomerulosclerosis, and tubulointerstitial nephritis) as disease control, and 20 healthy subjects. In primary MN, 18 of 25 sera (72 %) showed anti-α-enolase antibody (IgG1 and IgG4, 11 pts; IgG4 alone, six pts; IgG1 alone, one pt). In secondary MN, 15 of 20 sera (75 %) contained anti-α-enolase antibody (IgG1 and IgG3, 13 pts; IgG3 alone, two pts). No circulating anti-α-enolase antibody was found in 44 collagen diseases or septic patients, 60 nephritis without MN, and 20 healthy subjects. Twelve of 2...Continue Reading

References

Mar 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M Haas
Feb 1, 1996·Clinical Immunology and Immunopathology·G AdamusP A Hargrave
Dec 14, 1999·Clinical and Experimental Immunology·H WakuiA B Miura
Aug 11, 2001·Cellular and Molecular Life Sciences : CMLS·V Pancholi
Mar 29, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kiyotaka NagahamaAkira Yamada
Jun 28, 2002·The New England Journal of Medicine·Hanna DebiecPierre M Ronco
Jul 10, 2003·Autoimmunity Reviews·P MiglioriniS Bombardieri
Feb 10, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hiroshi OhtaniHirokazu Imai
Dec 3, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Roser Lopez-AlemanyPura Munoz-Canoves
Jan 20, 2007·Journal of Clinical Immunology·Agnieszka MagrysGrazyna Adamus
Feb 10, 2007·Autoimmunity Reviews·Benjamin TerrierLuc Mouthon
Sep 11, 2007·Internal Medicine·Harutaka YamadaHirokazu Imai
Jul 3, 2009·The New England Journal of Medicine·Laurence H BeckDavid J Salant
Feb 13, 2010·Journal of the American Society of Nephrology : JASN·Marco PrunottoGian Marco Ghiggeri
Feb 13, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Yoshie SegawaHiroshi Iwasaki
Apr 10, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Richard J Glassock
Jan 26, 2011·The FEBS Journal·Michela CapelloFrancesco Novelli
Feb 18, 2011·The New England Journal of Medicine·Hanna Debiec, Pierre Ronco
Mar 11, 2011·Clinical and Experimental Pharmacology & Physiology·Pierre Ronco, Hanna Debiec
May 14, 2011·Journal of the American Society of Nephrology : JASN·Weisong QinZhihong Liu
Jun 3, 2011·The New England Journal of Medicine·Hanna DebiecPierre Ronco
Mar 1, 2012·Nature Reviews. Nephrology·Pierre Ronco, Hanna Debiec
Jul 10, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Corrado MurtasGian Marco Ghiggeri
Nov 14, 2014·The New England Journal of Medicine·Nicola M TomasGérard Lambeau
Nov 22, 2014·Clinical and Experimental Nephrology·Shin'ichi AkiyamaShoichi Maruyama

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Citations

Mar 31, 2016·Clinical and Experimental Nephrology·Corrado MurtasGian Marco Ghiggeri
Jun 17, 2016·Clinical and Experimental Nephrology·Hirokazu Imai, Yukihiro Kimura
May 1, 2019·CEN Case Reports·Ayana IidaTakanori Shibata
Mar 8, 2018·BioMed Research International·Agnieszka PozdzikKarl Martin Wissing
Oct 18, 2019·Annual Review of Pathology·Pierre Ronco, Hanna Debiec
Jul 27, 2017·Terapevticheskiĭ arkhiv·V A DobronravovA V Smirnov
Sep 15, 2017·BioMed Research International·Andreas KronbichlerJae Il Shin
Jan 9, 2019·Frontiers in Immunology·Franziska von HaxthausenRolf A K Stahl
Aug 3, 2021·Journal of Immunology Research·Pingna ZhangWeijing Liu

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Methods Mentioned

BETA
electron microscopy
dot blot
biopsies
dot blots
biopsy
confocal microscopy

Software Mentioned

Adobe Photoshop

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