Abstract
Phospholipase A2 receptor (PLA2R) is recognized as a target antigen in primary membranous nephropathy (MN); Anti-α-enolase antibody in primary and secondary MN has been proposed, however, little is known about the potential contribution of α-enolase to the pathogenesis of MN. We evaluated circulating antibodies to α-enolase by a dot blotting system and PLA2R by indirect immunofluorescence, and glomerular deposition of these proteins in 25 patients with primary MN, 20 patients with secondary MN, 44 patients with collagen disease or severe infection, 60 patients with nephritis (each ten patients of IgA nephropathy, focal segmental gloemrulosclerosis, minimal change nephrotic syndrome, membranoproliferative glomeurlonephritis, diabetic glomerulosclerosis, and tubulointerstitial nephritis) as disease control, and 20 healthy subjects. In primary MN, 18 of 25 sera (72 %) showed anti-α-enolase antibody (IgG1 and IgG4, 11 pts; IgG4 alone, six pts; IgG1 alone, one pt). In secondary MN, 15 of 20 sera (75 %) contained anti-α-enolase antibody (IgG1 and IgG3, 13 pts; IgG3 alone, two pts). No circulating anti-α-enolase antibody was found in 44 collagen diseases or septic patients, 60 nephritis without MN, and 20 healthy subjects. Twelve of 2...Continue Reading
References
Mar 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M Haas
Feb 1, 1996·Clinical Immunology and Immunopathology·G AdamusP A Hargrave
Dec 1, 1995·Journal of Autoimmunity·M WalterW Northemann
Jan 1, 1997·Kidney International·H ImaiA B Miura
Jan 8, 1999·Journal of Autoimmunity·G AdamusM Machnicki
Dec 14, 1999·Clinical and Experimental Immunology·H WakuiA B Miura
Feb 13, 2001·European Journal of Immunology·S MoscatoP Migliorini
Aug 11, 2001·Cellular and Molecular Life Sciences : CMLS·V Pancholi
Mar 29, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kiyotaka NagahamaAkira Yamada
Jun 28, 2002·The New England Journal of Medicine·Hanna DebiecPierre M Ronco
Jul 13, 2002·Arthritis and Rheumatism·Vincent SaulotFrançois Tron
Dec 19, 2002·Internal Medicine·Aki KurokiTetsuzo Sugisaki
Jul 10, 2003·Autoimmunity Reviews·P MiglioriniS Bombardieri
Feb 10, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hiroshi OhtaniHirokazu Imai
Oct 7, 2004·Lancet·Hanna DebiecPierre Ronco
Dec 3, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Roser Lopez-AlemanyPura Munoz-Canoves
Apr 19, 2005·Journal of Neuroimmunology·A FujiiM Kuriyama
Jan 20, 2007·Journal of Clinical Immunology·Agnieszka MagrysGrazyna Adamus
Feb 10, 2007·Autoimmunity Reviews·Benjamin TerrierLuc Mouthon
Sep 11, 2007·Internal Medicine·Harutaka YamadaHirokazu Imai
Feb 2, 2008·Proteomics·Amélie ServettazLuc Mouthon
Jul 3, 2009·The New England Journal of Medicine·Laurence H BeckDavid J Salant
Feb 13, 2010·Journal of the American Society of Nephrology : JASN·Marco PrunottoGian Marco Ghiggeri
Feb 13, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Yoshie SegawaHiroshi Iwasaki
Apr 10, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Richard J Glassock
Jan 26, 2011·The FEBS Journal·Michela CapelloFrancesco Novelli
Feb 18, 2011·The New England Journal of Medicine·Hanna Debiec, Pierre Ronco
Mar 11, 2011·Clinical and Experimental Pharmacology & Physiology·Pierre Ronco, Hanna Debiec
May 14, 2011·Journal of the American Society of Nephrology : JASN·Weisong QinZhihong Liu
Jun 3, 2011·The New England Journal of Medicine·Hanna DebiecPierre Ronco
Jun 7, 2011·Journal of Proteomics·Maurizio BruschiGian Marco Ghiggeri
Mar 1, 2012·Nature Reviews. Nephrology·Pierre Ronco, Hanna Debiec
Jun 8, 2012·Kidney International·Elion HoxhaRolf A K Stahl
Jul 10, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Corrado MurtasGian Marco Ghiggeri
Nov 14, 2014·The New England Journal of Medicine·Nicola M TomasGérard Lambeau
Nov 22, 2014·Clinical and Experimental Nephrology·Shin'ichi AkiyamaShoichi Maruyama
Citations
Mar 31, 2016·Clinical and Experimental Nephrology·Corrado MurtasGian Marco Ghiggeri
Jun 17, 2016·Clinical and Experimental Nephrology·Hirokazu Imai, Yukihiro Kimura
May 1, 2019·CEN Case Reports·Ayana IidaTakanori Shibata
Mar 8, 2018·BioMed Research International·Agnieszka PozdzikKarl Martin Wissing
Oct 18, 2019·Annual Review of Pathology·Pierre Ronco, Hanna Debiec
Jul 27, 2017·Terapevticheskiĭ arkhiv·V A DobronravovA V Smirnov
Jul 18, 2020·Renal Failure·Peihong YinFengxian Huang
Aug 11, 2018·Medicine·Zhenbin JiangLi Zuo
Oct 31, 2017·Journal of Nephrology·A RadiceRenato A Sinico
May 15, 2018·Frontiers in Medicine·Weiying LiPing Fu
Sep 15, 2017·BioMed Research International·Andreas KronbichlerJae Il Shin
Jan 9, 2019·Frontiers in Immunology·Franziska von HaxthausenRolf A K Stahl
Aug 18, 2020·Autoimmunity Reviews·Inga Koneczny
Apr 24, 2021·Scientific Reports·Chenxi LiBing Gu
Aug 3, 2021·Journal of Immunology Research·Pingna ZhangWeijing Liu