Circulating antibodies to a conserved epitope of the Chlamydia trachomatis 60-kDa heat shock protein is associated with decreased spontaneous fertility rate in ectopic pregnant women treated by salpingectomy

American Journal of Reproductive Immunology : AJRI
István SzillerSteven S Witkin

Abstract

This prospective study was aimed to evaluate whether non-invasive clinical and serologic parameters of tubal disease are predictive for subsequent spontaneous conception and pregnancy outcome after first episode of ectopic pregnancy (EP). Overall, 144 women aged <35 years were enrolled. Outcome of subsequent spontaneous conception was analyzed after 3 years and compared with clinical parameters and antibody responses to Chlamydia trachomatis and epitopes of the 60-kDa chlamydial heat shock protein (CHSP-60). Antibody response to a conserved epitope of CHSP-60 (amino acids, aa 260-277) was independently correlated with both decreased spontaneous conception and term delivery rates (adjusted odds ratios, OR: 3.6 and 5.4, respectively). Presence of circulating antibodies to a conserved epitope of the CHSP-60 is associated with a lower spontaneous conception rate, and increased likelihood of adverse pregnancy outcome in women treated by salpingectomy for first episode of EP.

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Citations

Sep 29, 2011·Infectious Diseases in Obstetrics and Gynecology·Amanda J StephensDanny J Schust
Jul 12, 2011·Fertility and Sterility·Allison K RodgersGuangming Zhong
Aug 19, 2008·Fertility and Sterility·Päivi Joki-KorpelaAila Tiitinen
Aug 25, 2017·Clinical and Vaccine Immunology : CVI·Steven S WitkinIara M Linhares

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