Circulating antigen tests and urine reagent strips for diagnosis of active schistosomiasis in endemic areas

The Cochrane Database of Systematic Reviews
Eleanor A OchodoMariska Leeflang

Abstract

Point-of-care (POC) tests for diagnosing schistosomiasis include tests based on circulating antigen detection and urine reagent strip tests. If they had sufficient diagnostic accuracy they could replace conventional microscopy as they provide a quicker answer and are easier to use. To summarise the diagnostic accuracy of: a) urine reagent strip tests in detecting active Schistosoma haematobium infection, with microscopy as the reference standard; and b) circulating antigen tests for detecting active Schistosoma infection in geographical regions endemic for Schistosoma mansoni or S. haematobium or both, with microscopy as the reference standard. We searched the electronic databases MEDLINE, EMBASE, BIOSIS, MEDION, and Health Technology Assessment (HTA) without language restriction up to 30 June 2014. We included studies that used microscopy as the reference standard: for S. haematobium, microscopy of urine prepared by filtration, centrifugation, or sedimentation methods; and for S. mansoni, microscopy of stool by Kato-Katz thick smear. We included studies on participants residing in endemic areas only. Two review authors independently extracted data, assessed quality of the data using QUADAS-2, and performed meta-analysis where ...Continue Reading

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Citations

Aug 25, 2015·International Journal of Public Health·Chalotte Willemann StecherEskild Petersen
Aug 1, 2015·Clinical Microbiology Reviews·Kosala G A D WeerakoonDonald P McManus
Nov 19, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Zhu ZhanHong Ren
Sep 20, 2017·International Journal of Public Health·Afona ChernetNiklaus D Labhardt
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Aug 11, 2018·Nature Reviews. Disease Primers·Donald P McManusXiao-Nong Zhou
Jul 3, 2021·Tropical Medicine and Infectious Disease·Oyime Poise AulaCatherine A Gordon

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Methods Mentioned

BETA
urine filtration
ELISA
biopsy
enzyme‐linked immunosorbent assay
PCR
Antigen assay

Software Mentioned

SAS
Review Manager
QUADAS
Quality Assessment of Diagnostic Accuracy Studies ( QUADAS ‐ 2 )

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