Circulating antithyroid antibodies contribute to the decrease of glomerular filtration rate in lithium-treated patients: a longitudinal study

International Journal of Bipolar Disorders
Alberto BocchettaAntonello Pani

Abstract

Concerns about the adverse effects of long-term treatment with lithium include reduced renal function. In the present study, we examined comorbidities which may be associated with chronic kidney disease in a cohort of patients treated with lithium for up to 41 years. We studied 394 patients who were treated with lithium for ≥ 5 years. The potential role of comorbidities (diabetes, concurrent antihypertensive medication, treatment with L-thyroxine, and presence of antithyroid peroxidase/microsomes, anti-thyroglobulin, and/or anti-thyrotropin-receptor antibodies) was analysed. We focused on the categories of patients with an estimated glomerular filtration rate (eGFR) lower than 60 or 45 mL/min/1.73 m2 as calculated from serum creatinine according to the Modification of Diet in Renal Disease Study Group. We applied multivariate regression analysis and Cox survival analysis to study the effects exerted by sex, age, duration of lithium treatment, and comorbidities using eGFR categories as the dependent variable. Kaplan-Meier curves were generated to measure the time to decline to an eGFR lower than 45 mL/min/1.73 m2 in patients with positive or negative thyroid antibodies. Age was associated with a decline to an eGFR lower than 60 ...Continue Reading

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Citations

Jul 23, 2019·International Journal of Bipolar Disorders·Leonardo TondoUNKNOWN International Group for Studies of Lithium (IGSLi)
Sep 2, 2020·The Journal of International Medical Research·Qiaojing QinHeyuan Ding
Sep 8, 2020·Expert Opinion on Drug Safety·Laura OrsoliniUmberto Volpe

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