Circulating Apoptotic Signals During Acute and Chronic Exposure to High Altitude in Kyrgyz Population

Frontiers in Physiology
Djuro KosanovicRalph Theo Schermuly

Abstract

Background: Circulating apoptotic signals (CASs) have been described in the pathologies associated with dysregulated apoptosis, such as cancer, heart diseases, and pulmonary hypertension (PH). However, nothing is known about the expression profiles of these markers in the circulation of humans exposed to acute and chronic effects of high altitude (HA). Methods: Gene expression levels of different apoptotic signals (ASs) were analyzed in human pulmonary artery smooth muscle cells (PASMCs) upon hypoxia incubation. In addition, we measured the plasma values of relevant CAS in Kyrgyz volunteers during acute and chronic exposure to HA. Finally, we analyzed the effects of pro-apoptotic mediator Fas ligand (FasL) on apoptosis and proliferation of human PASMCs. Results: Several cellular AS were increased in PASMCs exposed to hypoxia, in comparison to normoxia condition. Among analyzed CAS, there was a prominent reduction of FasL in lowlanders exposed to HA environment. Furthermore, decreased circulatory levels of FasL were found in highlanders with HA-induced PH (HAPH), as compared to the lowland controls. Furthermore, FasL concentration in plasma negatively correlated with tricuspid regurgitant gradient values. Finally, FasL exerted p...Continue Reading

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Citations

Feb 14, 2021·International Journal of Environmental Research and Public Health·Akylbek SydykovRalph Theo Schermuly
Aug 13, 2020·Burns : Journal of the International Society for Burn Injuries·Xin Le, Wei-Wei Wu
Mar 27, 2021·Respiratory Physiology & Neurobiology·Walter S Calderón-Gerstein, Gabriela Torres-Samaniego

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Methods Mentioned

BETA
ICE
PCR
electrophoresis
ELISA
enzyme-linked immunosorbent assay

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