Circulating betatrophin is elevated in patients with type 1 and type 2 diabetes

Endocrine Journal
Hodaka YamadaSan-E Ishikawa

Abstract

There is evidence that betatrophin, a hormone derived from adipose tissue and liver, affects the proliferation of pancreatic beta cells in mice. The aim of this study was to examine circulating betatrophin concentrations in Japanese healthy controls and patients with type 1 and type 2 diabetes. A total of 76 subjects (12 healthy controls, 34 type 1 diabetes, 30 type 2 diabetes) were enrolled in the study. Circulating betatrophin was measured with an ELISA kit and clinical parameters related to betatrophin were analyzed statistically. Circulating betatrophin (Log transformed) was significantly increased in patients with diabetes compared with healthy subjects (healthy controls, 2.29 ± 0.51; type 1 diabetes, 2.94 ± 0.44; type 2 diabetes, 3.17 ± 0.18; p<0.001, 4.1 to 5.4 times in pg/mL order). Age, HbA1c, fasting plasma glucose and Log triglyceride were strongly associated with Log betatrophin in all subjects (n=76) in correlation analysis. In type 1 diabetes, there was a correlation between Log betatrophin and Log CPR. These results provide the first evidence that circulating betatrophin is significantly elevated in Japanese patients with diabetes. The findings of this pilot study also suggest a possibility of association between...Continue Reading

References

Jul 5, 2002·The Journal of Biological Chemistry·Tetsuya ShimizugawaHidehiko Furukawa
Mar 2, 2006·Experimental Animals·Kazunori FujimotoYosuke Ando
Apr 3, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Seiichi MatsuoUNKNOWN Collaborators developing the Japanese equation for estimated GFR
Jul 20, 2012·Biochemical and Biophysical Research Communications·Ren Zhang
Nov 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Fabiana QuagliariniHelen H Hobbs
Dec 25, 2012·Biochemical and Biophysical Research Communications·Zhiyao FuRen Zhang
Feb 19, 2013·Biochemical and Biophysical Research Communications·Ren Zhang, Abdul B Abou-Samra
Aug 24, 2013·The New England Journal of Medicine·Philip A Seymour, Palle Serup
Sep 18, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yan WangHelen H Hobbs
Feb 15, 2014·Nature Reviews. Drug Discovery·Amedeo VetereBridget K Wagner
Oct 19, 2010·Journal of Diabetes Investigation·Yutaka SeinoKohjiro Ueki
May 24, 2014·Scientific Reports·Zhiyao FuRen Zhang
Jun 26, 2014·International Journal of Endocrinology·Daniel EspesPer-Ola Carlsson
Jul 23, 2014·The Journal of Clinical Endocrinology and Metabolism·Javier Gómez-AmbrosiGema Frühbeck
Nov 25, 2014·Cell·Viktoria GusarovaJesper Gromada

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Citations

Dec 24, 2015·Journal of Diabetes Research·Sheyu LiHaoming Tian
Oct 26, 2016·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Kaifeng GuoWeiping Jia
Oct 16, 2015·Current Diabetes Reports·Daniel EspesPer-Ola Carlsson
Aug 21, 2015·Cardiovascular Diabetology·Mohamed Abu-FarhaNaser Elkum
Jun 18, 2016·Journal of Diabetes and Its Complications·Nasser M Al-DaghriMajed S Alokail
Jun 9, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Gulcin Sahin ErsoyOzge Cevik
Jun 27, 2015·PloS One·Natalia Wawrusiewicz-KurylonekMaria Gorska
Sep 28, 2016·Journal of Diabetes Research·Mohamed Abu-FarhaJehad Abubaker
Oct 4, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Gulcin Sahin ErsoyOzge Cevik
Feb 23, 2017·The Journal of International Medical Research·Qinglan QuQiuhua Yang
Mar 4, 2017·PloS One·Lukas MaurerThomas Bobbert
Dec 29, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Meryem Kurek EkenOzge Cevik
Jan 6, 2016·Chonnam Medical Journal·Hassan GhasemiJamshid Karimi
Feb 20, 2020·Journal of Clinical Medicine·Leonardo Catalano-IniestaMaría José García-Barrado
Mar 11, 2020·American Journal of Physiology. Endocrinology and Metabolism·Lu ZhangLuke Norton
Jun 9, 2016·Oncotarget·Hendra SusantoChih-Hong Wang
Sep 25, 2017·The Journal of Clinical Endocrinology and Metabolism·Raghavendra MysoreP A Nidhina Haridas
May 3, 2018·Frontiers in Endocrinology·Mengdie Luo, Daoquan Peng
Dec 14, 2018·Frontiers in Endocrinology·Abdulmohsen Al-TerkiJehad A Abubaker
Sep 23, 2018·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Filiz Eksi HaydardedeogluMelek Eda Ertorer
Jul 20, 2017·Diabetes/metabolism Research and Reviews·Mohamed Abu-FarhaJaakko Tuomilehto
Jul 30, 2017·G3 : Genes - Genomes - Genetics·Maren E CannonKaren L Mohlke

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