PMID: 2121399Oct 1, 1990Paper

Circulating bioactive follicle stimulating hormone and immunoreactive inhibin levels during the normal human menstrual cycle

Clinical Endocrinology
K ReddiS G Hillier

Abstract

To examine the relationship between circulating levels of bioactive FSH (B-FSH) and immunoactive inhibin and oestradiol we studied five women during ovulatory cycles. Daily blood samples were collected from each subject during one menstrual cycle. B-FSH was measured using a modified, highly sensitive in-vitro rat granulosa cell bioassay. The inclusion of IGF-1 (10 micrograms/l) and transferrin (50 mg/l) in the assay system enhanced granulosa cell responsiveness to FSH and resulted in increased assay sensitivity. Inhibin was measured by a heterologous radioimmunoassay (RIA) using an antibody raised against 31 kDa bovine inhibin. Bioactive FSH (B-FSH) levels were closely correlated to those of immunoactive FSH (I-FSH, r = 0.79, P less than 0.001) throughout the cycle. Peak levels of B-FSH were observed during the early follicular phase (day -13, 44.7 +/- 9.6 IU/l, mean +/- SEM) and during the midcycle surge (35.2 +/- 6.2 IU/l); lowest levels occurring during the luteal phase (nadir 3.9 +/- 0.27 IU/l). Plasma oestradiol levels increased significantly during the follicular phase (P less than 0.001) to a peak on day -1 and were negatively correlated with B-FSH during the late follicular phase (day -8 to -1; r = -0.45, P less than 0....Continue Reading

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Citations

May 30, 1998·Biochemical Pharmacology·T K Woodruff
Dec 20, 1996·Molecular and Cellular Endocrinology·S Christin-Maitre, P Bouchard
Jul 22, 1998·Animal Reproduction Science·K P McNattyB J McLeod
Aug 27, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·O J GintherR A Pierson
Dec 31, 2004·Obstetrics and Gynecology·Jennifer F CulhaneSecondo Guaschino
Feb 13, 2003·Clinical Endocrinology·Stephen TongHenry G Burger
Aug 1, 1991·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·E NagyP A Mårdh
Jan 1, 1992·British Journal of Obstetrics and Gynaecology·P E HayR F Lamont
Oct 1, 1996·British Journal of Obstetrics and Gynaecology·E M Wallace, D L Healy
Feb 1, 1997·Endocrine Reviews·B C Fauser, A M Van Heusden
Dec 1, 1991·Risk Analysis : an Official Publication of the Society for Risk Analysis·F Noonan
Mar 4, 2000·Endocrine Reviews·M P RoseA H Balen
Feb 1, 1996·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·F Scheele, J Schoemaker
Dec 1, 1991·Journal of Endocrinological Investigation·M Simoni, E Nieschlag
Apr 15, 2000·Methods : a Companion to Methods in Enzymology·S Christin-MaitreP Bouchard

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