Circulating biomarkers for monitoring therapy response and detection of disease progression in lung cancer patients.

Cancer Treatment and Research Communications
Remco de KockBirgit Deiman

Abstract

Liquid biopsies have become of interest as minimally invasive ways to monitor treatment response in lung cancer patients. Circulating tumor DNA (ctDNA) and protein biomarkers are evaluated for their added value in monitoring therapy response and early detection of disease progression. Plasma and serum samples of non-small cell or small cell lung cancer patients were analyzed for driver mutations in ctDNA (EGFR, KRAS or BRAF) using droplet digital PCR and protein biomarkers (CA125, CEA, CA15.3, Cyfra 21-1, HE4, NSE, proGRP and SCCA) using electrochemiluminescence immunoassays. Biomarker concentration changes were compared with the outcome of CT-scans during therapy. The median difference of the concentration of ctDNA, CA125 and Cyfra21-1 was significantly lower in patients with partial response (PR) compared to patients with progressive disease (PD) on the first evaluation CT-scan (P<0.001, P=0.042 and P=0.020, respectively). A substantial agreement between ctDNA or CA125 response and radiographic response was observed (k=0.692 and k=0.792, respectively). The median difference of the concentration of ctDNA and Cyfra21-1 was also significantly lower in PR patients compared to PD patients at the last CT-scan during therapy (P<0.00...Continue Reading

References

Aug 2, 2008·Nature Medicine·Frank DiehlLuis A Diaz
May 29, 2013·International Journal of Molecular Sciences·Dangfan YuGuojun Chen
Jan 17, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Geoffrey R OxnardPasi A Jänne
Jan 23, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Luis A Diaz, Alberto Bardelli
May 16, 2014·Clinical Chemistry and Laboratory Medicine : CCLM·Béla NagyPéter Antal-Szalmás
Oct 16, 2015·American Journal of Respiratory and Critical Care Medicine·Rafael MolinaAlvar Agusti
Nov 13, 2015·The International Journal of Biological Markers·Lishui WangChuanxin Wang
Feb 7, 2017·Clinical Laboratory·Ewa WojcikJan K Kulpa
Jan 14, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sarah B GoldbergAbhijit A Patel
Jun 10, 2018·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Christian RolfoDavid R Gandara
Jul 16, 2019·Molecular Oncology·Johanne A HojbjergBoe S Sorensen
Oct 28, 2019·EBioMedicine·Anne Tranberg MadsenAnne Winther-Larsen
Dec 15, 2019·The Journal of Molecular Diagnostics : JMD·Christina M Wood-BouwensHanlee P Ji
Jan 17, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Aparna R ParikhRyan B Corcoran
Jan 29, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G SiravegnaA Bardelli
Jan 25, 2021·The Journal of Molecular Diagnostics : JMD·Remco de KockBirgit Deiman

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