Circulating brain-reactive autoantibodies and behavioral deficits in the MRL model of CNS lupus.

Journal of Neuroimmunology
S WilliamsS A Hoffman

Abstract

Brain-reactive autoantibodies (BRAA) are hypothesized to play a role in the neuropsychiatric manifestations that accompany systemic lupus erythematosus (SLE). The present study tests the proposed relation between circulating BRAA and behavioral deficits in lupus-prone MRL/lpr mice. Two age-matched cohorts born at different times were used to test the relationship in the context of altered disease severity. Significant correlations between autoimmunity and behavior were detected in both cohorts. These results are the first to report correlations between behavior and autoantibodies to integral membrane proteins of brain, supporting the hypothesis that BRAA contribute to the behavioral dysfunction seen in lupus.

References

Mar 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·S E Martin, W J Martin
Feb 1, 1976·The Journal of Clinical Investigation·H G Bluestein, N J Zvaifler
Aug 1, 1979·Clinical Immunology and Immunopathology·R J HarbeckD W Shucard
Jan 1, 1979·Journal of Immunological Methods·S AotsukaR Yokohari
Sep 1, 1992·Brain, Behavior, and Immunity·B SakićJ A Denburg
Jan 1, 1992·Neuroscience and Biobehavioral Reviews·P WillnerM Papp
Apr 27, 1992·Journal of Immunological Methods·J Crimando, S A Hoffman
Mar 1, 1991·International Immunology·B TangT Kishimoto
Dec 1, 1990·Journal of Neuroimmunology·S A Hoffman, C S Madsen
Nov 10, 1988·Journal of Immunological Methods·A Narendran, S A Hoffman
Jan 1, 1987·Journal of Neuroimmunology·N Schupf, C A Williams
Mar 1, 1969·Archives of General Psychiatry·G F SolomonA Amkraut
Sep 1, 1994·Physiology & Behavior·B SakićJ A Denburg
Nov 1, 1993·Physiology & Behavior·B SakićJ A Denburg
Oct 1, 1993·Annals of Medicine·R GanguliB S Rabin
Mar 31, 1993·Behavioural Brain Research·B SakićJ A Denburg
May 1, 1993·Journal of Neuroimmunology·N A Khin, S A Hoffman
Jan 1, 1996·Brain Research Bulletin·B SakićH Szechtman
Sep 1, 1996·Current Opinion in Rheumatology·S G West
May 1, 1997·Neuroscience and Biobehavioral Reviews·B SakićJ A Denburg
Jan 1, 1997·Brain Research Bulletin·B SakićJ A Denburg
May 16, 1998·Biological Psychiatry·Y K KimK Y Suh
Jul 15, 1998·Journal of Neuroimmunology·S A HoffmanR J Harbeck
Jul 22, 1998·Journal of Neuroimmunology·B SakićI Q Whishaw
Mar 14, 2000·Journal of Neuroimmunology·B SakicJ A Denburg
May 16, 2001·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·V M GitlitsB H Toh
Nov 6, 2001·Journal of Neuroimmunology·A Zameer, S A Hoffman
Feb 11, 2003·Brain Research·David A BallokBoris Sakic
Mar 20, 2003·Behavioural Brain Research·David A BallokBoris Sakic
Sep 11, 2003·Journal of Neuroimmunology·Susumu TanakaNobuyuki Amino
Apr 1, 1962·Archives of General Psychiatry·W J FESSEL
Aug 1, 1964·Angiology·G F SOLOMONW J FESSEL
Sep 27, 2003·Journal of Neuroimmunology·Andleeb Zameer, Steven A Hoffman
Oct 24, 2003·Psychiatry Research·Klaus SchottGerhard Buchkremer
Dec 31, 2003·Journal of Neuroimmunology·Andleeb Zameer, S A Hoffman
Jan 13, 2004·Lupus·N J AbbottD E M Dolman
Aug 11, 2004·Hippocampus·David A BallokBoris Sakic

❮ Previous
Next ❯

Citations

Feb 1, 2014·Neuroscience and Biobehavioral Reviews·Rosebella Alungata IsemeFrederick Rohan Walker
Feb 19, 2011·Journal of Biomedicine & Biotechnology·Maria Gulinello, Chaim Putterman
Jun 9, 2014·BMC Immunology·Stephanie WilliamsSteven A Hoffman
Jun 24, 2014·PloS One·Minesh KapadiaBoris Sakic
Feb 5, 2013·Schizophrenia Bulletin·Guglielmo LuccheseDarja Kanduc
Sep 4, 2014·Autoimmunity Reviews·Hélène Jeltsch-David, Sylviane Muller
Sep 6, 2011·Progress in Neurobiology·Minesh Kapadia, Boris Sakic
Apr 13, 2017·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Minesh KapadiaBoris Sakic
Jul 21, 2015·European Psychiatry : the Journal of the Association of European Psychiatrists·R A IsemeM Boyle

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Blood Brain Barrier & Cytokines

Some cytokines are able to cross the blood brain barrier through transport systems and enter the cerebrospinal fluid and interstitial fluid spaces. Here is the latest research on cytokines crossing the blood brain barrier and how this can affect tissues within the CNS.

Anti-N-Methyl-D-Aspartate Receptor Encephalitis

Anti-N-Methyl-D-Aspartate (NMDA) receptor encephalitis is a form of of brain inflammation due to antibodies against NMDA receptors. Discover the latest research on anti-NMDA receptor encephalitis here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.