Circulating CD105 shows significant impact in patients of oral cancer and promotes malignancy of cancer cells via CCL20

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Chang-Han ChenChih-Yen Chien

Abstract

CD105 is rich in endothelium cells and is involved in angiogenesis. Higher microvascular density of tumor is also related to the prognosis in a variety of cancers. In this present study, patients with positive N classification, advanced T classification, advanced TNM stage, extracapsular spread of lymph nodes (ECS), and perineural invasion had significantly higher levels of peripheral vein (pCD105) and venous return from tumor (tCD105) in 71 patients with OSCC compared to 13 healthy volunteers. Those with higher pCD105 or tCD105 levels had significantly poorer 5-year disease-specific survival rate (DDS) and overall survival rate (OS). The tCD105 and pCD105 levels and ECS were the independent prognostic factors by the multivariate analysis according to the Cox regression model in 5-year DDS and OS rate. SAS and SCC4 cells treated with CD105 showed the increase in migration, invasion, and proliferation in vitro and in vivo. Furthermore, CCL20 expression participated in CD105-elicited cell motility in oral cancer cells. In conclusion, higher level of circulating CD105 is related to adverse pathological features among patients with OSCC. It is also a useful marker for evaluating the prognosis and targeting therapeutics of OSCC.

References

May 29, 1999·Science·D Y LiD P Wendel
Feb 7, 2001·International Journal of Cancer. Journal International Du Cancer·C LiS Kumar
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Oct 9, 2002·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·E TorsneyH M Arthur
Jan 25, 2003·Journal of Biochemistry and Molecular Biology·Kyu-Sil ChoiKyu-Won Kim
May 30, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sarah E DuffShant Kumar
Jun 11, 2004·The New England Journal of Medicine·Jin-Ching LinRong-San Jiang
Sep 24, 2004·The EMBO Journal·Franck LebrinPeter ten Dijke
Feb 8, 2005·Oral Oncology·Tiziana MartoneGiorgio Cortesina
May 6, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Alex Bobik
May 25, 2006·Acta Oto-laryngologica·Gino MarioniCosimo De Filippis
Jul 11, 2006·The Laryngoscope·Hui-Ching ChuangChao-Cheng Huang
Apr 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nikolaos A DallasLee M Ellis
Jun 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert S SvatekShahrokh F Shariat
Jan 12, 2010·Biochemical and Biophysical Research Communications·Fei TianLevent M Akyürek
Jan 15, 2010·Clinical and Experimental Otorhinolaryngology·Dae-Young HongJung-Hoon Ro
Nov 19, 2010·Radiation and Environmental Biophysics·Hendrik A WolffHans Christiansen
Feb 23, 2011·Archives of Otolaryngology--head & Neck Surgery·Gino MarioniStella Blandamura
Aug 20, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Olivier CalvayracJosé Martínez-González
Nov 11, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Xiangjiu DingSanyuan Hu
Jul 7, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lee S RosenMichael S Gordon
Oct 2, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Marion ScharpfeneckerFiona A Stewart
Jan 19, 2013·Expert Opinion on Therapeutic Targets·Madelon PaauweLukas J A C Hawinkels
Oct 4, 2014·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Leon Jonker

❮ Previous
Next ❯

Citations

Oct 5, 2019·Pathology, Research and Practice·Gino MarioniElisabetta Zanoletti
Sep 20, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Priyanka Bhattacharya, Rajarshi Mukherjee
Apr 4, 2021·International Journal of Molecular Sciences·Ming-Huei ChouChih-Yen Chien

❮ Previous
Next ❯

Related Concepts

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.