Circulating CD8+ T-cell repertoires reveal the biological characteristics of tumors and clinical responses to chemotherapy in breast cancer patients

Cancer Immunology, Immunotherapy : CII
Kai-Rong LinWei Luo

Abstract

CD8+ T cells are primarily cytotoxic cells that provide immunological protection against malignant cells. Considerable evidence suggests that the T-cell repertoire is closely associated with the host immune response and the development of cancer. In this study, we explored the characteristics of the circulating CD8+ T-cell repertoire and their potential value in predicting the clinical response of breast cancer patients to chemotherapy. We applied a high-throughput TCR β-chain sequencing method to characterize the CD8+ T-cell repertoire of the peripheral blood from 26 breast cancer patients. In addition, changes in the circulating CD8+ T-cell repertoire during chemotherapy were analyzed. We found that the HEC ratios of the CD8+ T-cell repertoires from HER2+ breast cancer patients were significantly higher than those of HER2- patients, suggesting that the HER2 protein is released into circulation where it is targeted by CD8+ T cells. Several Vβ and CDR3 motifs preferentially used in HER2+ patients were identified. Besides, we found that the circulating CD8+ T-cell repertoires evolved during chemotherapy and correlated with patient clinical responses to chemotherapy. Increased CD8+ T-cell repertoire heterogeneity during chemother...Continue Reading

References

May 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sonia A PerezMichael Papamichail
Jun 23, 2009·Genome Research·J Douglas FreemanRobert A Holt
Mar 3, 2011·Nature Reviews. Clinical Oncology·Laurence ZitvogelGuido Kroemer
May 30, 2014·Science Translational Medicine·Edward ChaLawrence Fong
Apr 15, 2015·Journal of the American College of Surgeons·Brigid K KilleleaDonald R Lannin
Nov 20, 2015·Genome Medicine·Jörg J GoronzyCornelia M Weyand
Apr 5, 2016·Nature Communications·Tilman Schneider-HohendorfNicholas Schwab
Apr 8, 2016·Cancer Treatment Reviews·Maria Vittoria DieciValentina Guarneri
Jun 10, 2016·International Journal of Oncology·Jae-Hyun ParkYusuke Nakamura
Jun 22, 2017·Nature·Jacob GlanvilleMark M Davis
Feb 3, 2018·Scientific Reports·Aaron S MansfieldJin Jen

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Citations

Apr 6, 2020·The FEBS Journal·Amanda J OliverClare Y Slaney
Oct 14, 2019·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Amal Kamal Abdel-AzizSaverio Minucci
Apr 30, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Meng QiaoCaicun Zhou

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