Circulating cell free DNA as the diagnostic marker for colorectal cancer: a systematic review and meta-analysis

Oncotarget
Xin WangZi-Hua Chen

Abstract

Quantitative analyses of circulating cell-free DNA (cfDNA) are suggested to be a promising method for the detection of colorectal cancer, validated clinical relevance of cfDNA has not been published so far. Though some of the inconsistent results were published. This study is the first meta-analysis to systematically evaluate the diagnostic accuracy of circulating cfDNA as non-invasive biomarkers for colorectal cancer. Fourteen studies concerning a quantitative analysis of circulating cfDNA for the diagnosis of colorectal cancer met the inclusion criteria. Data includes 1,258 patients with colorectal cancer and 803 healthy individuals as control was analyzed. The summary estimates were as follow: sensitivity, 0.735 (95% CI 0.713-0.757); specificity, 0.918 (95% CI, 0.900-0.934); positive likelihood ratio, 8.295 (95% CI, 5.037-13.659); negative likelihood ratio, 0.300 (95% CI, 0.231-0.391); diagnostic odds ratio, 30.783 (95% CI, 16.965-55.856); and area under the curve, 0.8818 (95% CI, 0.88-0.93), respectively. Publication bias was not evident with Deeks' funnel plot asymmetry test (p = 0.197). A systematic literature was searched in PubMed, EMBASE, Cochrane Library and Chinese National Knowledge Infrastructure from their incepti...Continue Reading

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Citations

Nov 27, 2019·Intestinal research·Hyung-Hoon Oh, Young-Eun Joo
Feb 23, 2020·Hormone Molecular Biology and Clinical Investigation·Kajal NandiBinita Goswami
Jun 23, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·R VáraljaiA Roesch
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Jul 3, 2021·Cancers·Mehmet YalchinAilsa Hart

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STATA
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QUADAS
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