Circulating Cell-Free DNA Levels Could Predict Oncological Outcomes of Patients Undergoing Esophagectomy for Esophageal Squamous Cell Carcinoma

International Journal of Molecular Sciences
Chih-Cheng HsiehYann-Jang Chen

Abstract

Circulating cell-free DNA (cfDNA) is a potential biomarker for cancer progression but its role is unclear in patients with esophageal squamous cell carcinoma (ESCC) after esophagectomy. We investigated relationships between plasma cfDNA levels and clinicopathological parameters in ESCC patients. Eighty-one ESCC patients who received esophagectomy were enrolled. Plasma samples from these patients and 95 normal controls were collected. DNA copy numbers were measured by real-time quantitative PCR. Subjects were divided into two groups by cfDNA level. Clinicopathological data were collected retrospectively and relationships between cfDNA levels and clinical parameters were evaluated. The cfDNA level in normal controls ranged from 0-4157 copies/mL. The cfDNA level of 96.3% ESCC patients was higher than the cutoff value (2447.26 copies/mL) with a specificity of 94.1%. The mean cfDNA concentration was 5918 copies/mL in lower and 53,311 copies/mL in higher cfDNA groups. No correlations were found between clinicopathological factors and cfDNA levels except for lymphovascular invasion. Higher cfDNA levels were associated with tumor relapse (p = 0.018). Five-year disease-free survival (DFS) and overall survival (OS) rates were 34.7% and 3...Continue Reading

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Citations

Dec 26, 2018·Expert Review of Molecular Diagnostics·Wanli YangDaiming Fan
Aug 16, 2019·Cancers·Richard A JacobsonAshiq Masood
Aug 9, 2018·Frontiers in Oncology·Hariti SalujaErin L Symonds
Jun 18, 2020·World Journal of Clinical Cases·Long ChenPu Cheng
Dec 2, 2020·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Asmae GassaHakan Alakus
Jan 3, 2021·Cancer Genetics·Cemal Çağıl KoçanaSelçuk Sözer
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Aug 8, 2021·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·Patrick R JordanHenry Paul Redmond
Nov 10, 2021·ELife·Nicole Laurencia YuwonoCaroline Elizabeth Ford

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Methods Mentioned

BETA
PCR

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SPSS

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