Circulating Cell-Free DNA Levels Could Predict Oncological Outcomes of Patients Undergoing Esophagectomy for Esophageal Squamous Cell Carcinoma

International Journal of Molecular Sciences
Chih-Cheng HsiehYann-Jang Chen


Circulating cell-free DNA (cfDNA) is a potential biomarker for cancer progression but its role is unclear in patients with esophageal squamous cell carcinoma (ESCC) after esophagectomy. We investigated relationships between plasma cfDNA levels and clinicopathological parameters in ESCC patients. Eighty-one ESCC patients who received esophagectomy were enrolled. Plasma samples from these patients and 95 normal controls were collected. DNA copy numbers were measured by real-time quantitative PCR. Subjects were divided into two groups by cfDNA level. Clinicopathological data were collected retrospectively and relationships between cfDNA levels and clinical parameters were evaluated. The cfDNA level in normal controls ranged from 0-4157 copies/mL. The cfDNA level of 96.3% ESCC patients was higher than the cutoff value (2447.26 copies/mL) with a specificity of 94.1%. The mean cfDNA concentration was 5918 copies/mL in lower and 53,311 copies/mL in higher cfDNA groups. No correlations were found between clinicopathological factors and cfDNA levels except for lymphovascular invasion. Higher cfDNA levels were associated with tumor relapse (p = 0.018). Five-year disease-free survival (DFS) and overall survival (OS) rates were 34.7% and 3...Continue Reading


Nov 20, 1997·Current Problems in Surgery·H AkiyamaY Kajiyama
Feb 6, 1999·The American Journal of Gastroenterology·C J Lightdale
Mar 10, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J FaivreG Gatta
Oct 3, 1999·Cancer Metastasis Reviews·P AnkerM Stroun
Sep 12, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Naoyuki UmetaniDave S B Hoon
Sep 15, 2009·Clinical Biochemistry·Maniesh van der Vaart, Pieter J Pretorius
Apr 7, 2010·Annals of Surgical Oncology·Thomas W RiceValerie W Rusch
Aug 7, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Klaus JungAnja Rabien
May 13, 2011·Nature Reviews. Cancer·Heidi SchwarzenbachKlaus Pantel
Jan 10, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Karen-Lise Garm SpindlerAnders Jakobsen
Sep 26, 2013·International Journal of Molecular Sciences·Yahya I ElshimaliJaydutt V Vadgama
Sep 6, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Abel Jacobus BronkhorstPiet J Pretorius
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