Circulating complement factor H-related protein 5 levels contribute to development and progression of IgA nephropathy

Kidney International
Li ZhuHong Zhang

Abstract

IgA nephropathy (IgAN) is a disease associated with activation of the complement system. But the factors influencing complement activation in IgAN are not fully understood. Complement factor H (FH) is an essential negative regulator of complement C3 activation. Complement factor H-related protein (FHR)-5 shares high sequence similarity with factor H. However, unlike factor H, on binding to activated C3 it enables further activation to proceed. Previously, we reported the contribution of rare variants of the CFHR5 gene to IgAN susceptibility. Here we compared circulating levels of FHR-5 in 1126 patients with IgAN and regular follow-up with those of 153 unrelated healthy individuals to explore the relationship of FHR-5 levels with IgAN development and progression. Circulating FHR-5 levels were significantly elevated in patients with IgAN compared to healthy individuals (median 4.55 [interquartile range 3.58 to 5.85] μg/ml vs 3.19 [interquartile range 2.55 to 3.92] μg/ml). Higher circulating FHR-5 levels were associated with a lower estimated glomerular filtration rate, hypertension, and severe Oxford-T and Oxford-C scores. High FHR-5 levels were independently and significantly associated with a risk of developing either a 30% dec...Continue Reading

References

Sep 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·L P BartosikD C Cattran
Jan 5, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Brendan MurphyJennifer McRae
May 28, 2004·Molecular Immunology·Santiago Rodríguez de CórdobaPilar Sánchez-Corral
May 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jennifer L McRaeDavid L Gordon
May 12, 2006·Journal of the American Society of Nephrology : JASN·Anja RoosMohamed R Daha
Mar 28, 2007·Journal of Clinical Laboratory Analysis·Kisara OndaYasuhiko Tomino
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Jul 3, 2009·Kidney International·UNKNOWN Working Group of the International IgA Nephropathy Network and the Renal Pathology SocietyHong Zhang
Mar 15, 2011·Nature Genetics·Ali G GharaviRichard P Lifton
May 14, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Yiannis AthanasiouConstantinos Deltas
Sep 29, 2011·Journal of the American Society of Nephrology : JASN·Hitoshi SuzukiBruce A Julian
Mar 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Elena Goicoechea de JorgeSusan M Lea
Jun 4, 2013·The Journal of Clinical Investigation·Agustín TortajadaSantiago Rodríguez de Córdoba
Jul 9, 2013·Molecular Immunology·Christine SkerkaLubka T Roumenina
Jan 11, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Xiangling LiHong Zhang
May 28, 2014·Nature Reviews. Nephrology·Ian S D Roberts
Jan 31, 2016·Journal of the American Society of Nephrology : JASN·Ya-Ling ZhaiHong Zhang
Oct 27, 2016·Immunological Reviews·Nicholas Medjeral-Thomas, Matthew C Pickering
Mar 28, 2017·Kidney International·Hernán TrimarchiUNKNOWN Conference Participants
Jul 5, 2017·Kidney International·Nicholas R Medjeral-ThomasMatthew C Pickering

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Citations

May 31, 2019·Minerva medica·Sarah M Moran, Daniel C Cattran
Jan 26, 2020·Journal of the American Society of Nephrology : JASN·Peter F ZipfelChristine Skerka
Jan 1, 2020·International Journal of Molecular Sciences·Sofia AndrighettoPaolo Cravedi
Apr 3, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jamie S ChuaIngeborg M Bajema
Aug 18, 2018·Frontiers in Immunology·Anna E van BeekKyra A Gelderman
Apr 9, 2020·Frontiers in Medicine·Sheng Chang, Xiao-Kang Li
Oct 16, 2019·Frontiers in Immunology·Peter F ZipfelChristine Skerka
Nov 27, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rosanna Coppo
Feb 24, 2021·Clinical and Experimental Nephrology·Dan WuXiaorong Liu
Mar 24, 2021·Proceedings of the National Academy of Sciences of the United States of America·Talat H MalikMatthew C Pickering
Mar 27, 2021·Current Opinion in Nephrology and Hypertension·Nicholas R Medjeral-ThomasH Terence Cook
Apr 20, 2021·Frontiers in Immunology·Felix PoppelaarsUNKNOWN SciFiMed consortium
Jun 10, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Cheng ZhouMin Jiang
Jun 22, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Claudia SeikritJürgen Floege
Jul 6, 2021·Frontiers in Genetics·Gabriella GuzzoManuel Pascual
Jul 2, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Frederick Gyapon-QuastMatthew C Pickering
Aug 12, 2021·Seminars in Immunopathology·Nicholas R Medjeral-ThomasMatthew C Pickering
Aug 21, 2021·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Irene Gómez Delgado, Pilar Sánchez-Corral
Aug 22, 2021·Seminars in Immunopathology·Hong Zhang, Jonathan Barratt
Oct 7, 2021·Cell and Tissue Research·Peter F ZipfelChristine Skerka

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