Abstract
Growth differentiation factor 11 (GDF11) is member of the transforming growth factor β (TGF-β) superfamily of proteins. Circulating GDF11 concentrations appear to decline with age, and its depletion is associated with cardiac hypertrophy and other morbidities. Knowledge of GDF11 regulation is limited, and the effects of natural genetic variation on GDF11 levels are currently undefined. We tested whether genetic background determines serum GDF11 concentrations using two classical inbred mouse strains: C57BL/6J (B6) and BALB/cByJ (BALB). B6 mice exhibited significantly higher GDF11 levels than BALB mice, and these strain differences were consistent throughout the life span. Overall, interactions between age and genetic background determined GDF11 concentrations, which were unaffected by sex. We then surveyed a panel of 22 genetically diverse inbred mouse strains and discovered a sixfold range in GDF11 levels at middle age. We estimated that 74.52% of phenotypic variation in GDF11 levels was attributable to genetic background. We used the Mouse Phenome Database to screen for phenotypes that correlate with GDF11. Interestingly, GDF11 levels predicted median strain life spans. This study revealed high heritability of GDF11 levels. F...Continue Reading
References
Mar 1, 2006·Circulation·Kalliopi PilichouAlessandra Rampazzo
Dec 1, 2007·Biochemical and Biophysical Research Communications·Tetsuya NomuraHidemasa Oh
Apr 4, 2008·Genetics·Hyun Min KangEleazar Eskin
Jul 25, 2009·Aging Cell·Rong YuanBeverly Paigen
Mar 28, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Zoltan Ungvari, Anna Csiszar
May 9, 2012·Proceedings of the National Academy of Sciences of the United States of America·Rong YuanBeverly Paigen
May 15, 2013·Cell·Francesco S LoffredoRichard T Lee
Dec 7, 2013·PloS One·Lars WallentinAgneta Siegbahn
Dec 18, 2013·Aging Cell·Zhenwei GongShoshana Yakar
May 7, 2014·Science·Manisha SinhaAmy J Wagers
May 7, 2014·Science·Lida KatsimpardiLee L Rubin
Mar 27, 2015·Aging Cell·Christopher L MendiasJohn A Faulkner
May 24, 2015·Cell Metabolism·Marc A EgermanDavid J Glass
Aug 22, 2015·European Heart Journal·Kristoff A OlsonPeter Ganz
Sep 16, 2015·Endocrinology·Buel D Rodgers, Jennifer A Eldridge
Oct 23, 2015·Circulation Research·Tommaso PoggioliRichard T Lee
Oct 23, 2015·Mediators of Inflammation·Enrique Gallego-ColonJoanne Tonkin
Citations
Oct 6, 2016·Scientific Reports·Ying ZhangXiangmei Chen
Jul 14, 2017·Physiological Reports·Bradley T ElliottLawrence D Hayes
Sep 5, 2018·Physiological Reports·Lady V Barrios-SilvaBradley T Elliott
Jun 16, 2016·F1000Research·James A Timmons, Iain J Gallagher
Feb 7, 2019·Biogerontology·Yang ZhouShicui Zhang
Jun 15, 2017·Clinical Science·Rungong YangJie Bai
Nov 9, 2017·Oncotarget·Yonghui ZhangDilong Chen
May 24, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Xiaolin LiangQuanyang Li
Mar 22, 2019·Aging·Juan Añón-HidalgoJavier Gómez-Ambrosi
Nov 28, 2019·Molecular Biology Reports·Yoshinori Okada, Mizue Okada
Dec 7, 2018·Biogerontology·Yang ZhouShicui Zhang
Dec 1, 2018·BMC Bioinformatics·Hui XiaoPietro Lio'
Jun 30, 2019·Journal of Clinical Medicine·Juan Añón-HidalgoJavier Gómez-Ambrosi
Aug 13, 2017·Thorax·Ma'en Obeidat, Don D Sin
Feb 29, 2020·Ageing Research Reviews·Marta Gonzalez-FreireRafael de Cabo
Apr 23, 2021·Aging·Yuting MaXiaodong Sun
Aug 3, 2021·Oxidative Medicine and Cellular Longevity·Beatriz Mena-MontesArmando Luna-López
Nov 19, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Yang ZhouShicui Zhang