Circulating Concentrations of Growth Differentiation Factor 11 Are Heritable and Correlate With Life Span

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Yang ZhouRobert Pazdro

Abstract

Growth differentiation factor 11 (GDF11) is member of the transforming growth factor β (TGF-β) superfamily of proteins. Circulating GDF11 concentrations appear to decline with age, and its depletion is associated with cardiac hypertrophy and other morbidities. Knowledge of GDF11 regulation is limited, and the effects of natural genetic variation on GDF11 levels are currently undefined. We tested whether genetic background determines serum GDF11 concentrations using two classical inbred mouse strains: C57BL/6J (B6) and BALB/cByJ (BALB). B6 mice exhibited significantly higher GDF11 levels than BALB mice, and these strain differences were consistent throughout the life span. Overall, interactions between age and genetic background determined GDF11 concentrations, which were unaffected by sex. We then surveyed a panel of 22 genetically diverse inbred mouse strains and discovered a sixfold range in GDF11 levels at middle age. We estimated that 74.52% of phenotypic variation in GDF11 levels was attributable to genetic background. We used the Mouse Phenome Database to screen for phenotypes that correlate with GDF11. Interestingly, GDF11 levels predicted median strain life spans. This study revealed high heritability of GDF11 levels. F...Continue Reading

References

Mar 28, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Zoltan Ungvari, Anna Csiszar
May 9, 2012·Proceedings of the National Academy of Sciences of the United States of America·Rong YuanBeverly Paigen
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Citations

Oct 6, 2016·Scientific Reports·Ying ZhangXiangmei Chen
Sep 5, 2018·Physiological Reports·Lady V Barrios-SilvaBradley T Elliott
Jun 16, 2016·F1000Research·James A Timmons, Iain J Gallagher
May 24, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Xiaolin LiangQuanyang Li
Dec 1, 2018·BMC Bioinformatics·Hui XiaoPietro Lio'
Jun 30, 2019·Journal of Clinical Medicine·Juan Añón-HidalgoJavier Gómez-Ambrosi
Aug 13, 2017·Thorax·Ma'en Obeidat, Don D Sin
Feb 29, 2020·Ageing Research Reviews·Marta Gonzalez-FreireRafael de Cabo
Nov 19, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Yang ZhouShicui Zhang

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