Circulating concentrations of IGF-I and IGFBP-3 are not predictive of incidence or clinical behavior of pediatric osteosarcoma

Medical and Pediatric Oncology
C Rodriguez-GalindoJ L Cleveland

Abstract

Preclinical studies suggest a role of insulin-like growth factor-1 (IGF-1) in the proliferation of osteosarcoma cells in vivo. The purpose of this study is to address the relationship between serum levels of IGF-1 and its binding protein (IGFBP-3), and the clinical behavior and outcome of osteosarcoma in children, and to compare those levels present in osteosarcoma patients with a normal population. Serum IGF-1 and IGFBP-3 levels were determined by ELISA in 37 patients with osteosarcoma treated on the same treatment regimen (OS-91 protocol), and who had available serum samples from diagnosis. IGF-1 and IGFBP-3 levels were compared with those previously established in the normal population, matched for age and gender, and were correlated with the presence of metastatic disease, histologic response to preoperative chemotherapy, and event-free survival. In osteosarcoma patients the median IGF-1 level was 275 ng/ml (range, 105-613) and the median IGFBP-3 level was 3.4 mg/L (range, 2.3-5.1). IGF-1 levels differed from those in the normal population (P = 0.029); although we anticipated higher IGF-1 levels than normal children, 68% of observed standardized scores were less than 0. Furthermore, IGF-1 or IGFBP-3 levels failed to correla...Continue Reading

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Citations

May 17, 2012·Clinical Sarcoma Research·Yulia A SavitskayaJosé Clemente Ibarra-Ponce de León
Jan 30, 2007·Journal of Endocrinological Investigation·G A B LimaM R Gadelha
Apr 20, 2004·Journal of Cellular Biochemistry·E Gregory MacEwenRobert Radinsky
Apr 16, 2002·Clinical Orthopaedics and Related Research·Bruno Fuchs, Douglas J Pritchard

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