Circulating Concentrations of Redox Biomarkers Do Not Improve the Prediction of Adverse Cardiovascular Events in Patients With Type 2 Diabetes Mellitus

Journal of the American Heart Association
Maxime CournotSamy Hadjadj

Abstract

Despite pathophysiological relevance and promising experimental data, the usefulness of biomarkers of oxidative stress for cardiac risk prediction is unclear. The aim of our study was to investigate the prognostic value of 6 biomarkers exploring different pathways of oxidative stress for predicting adverse cardiovascular outcomes in patients with type 2 diabetes mellitus beyond established risk factors. The SURDIAGENE (Survie, Diabete de type 2 et Genetique) prospective cohort study consecutively recruited 1468 patients with type 2 diabetes mellitus. Assays were performed at baseline, and incident cases of major adverse cardiovascular events (MACE)-first occurrence of cardiovascular death, nonfatal myocardial infarction, or stroke-were recorded during a median of 64 months. Advanced oxidation protein products, oxidative hemolysis inhibition assay, ischemia-modified albumin, and total reductive capacity of plasma were not associated with the risk of MACE in univariate analyses. Fluorescent advanced glycation end products and carbonyls were associated with MACE (hazard ratio=1.38 per SD, 95% confidence interval 1.24-1.54,P<0.001 and hazard ratio=1.15 per SD, 95% confidence interval 1.04-1.27,P=0.006, respectively) in univariate a...Continue Reading

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Citations

Oct 16, 2018·Immunological Investigations·Josef FontanaVaclav Vetvicka
Jun 20, 2019·Oxidative Medicine and Cellular Longevity·Elisabetta Bigagli, Maura Lodovici
Aug 14, 2019·Journal of Managed Care & Specialty Pharmacy·Daniel J KentCatherine M Lockhart
Apr 27, 2021·Oxidative Medicine and Cellular Longevity·Mateusz MaciejczykKarolina Gerreth

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Methods Mentioned

BETA
Assay
ELISA
glycation

Software Mentioned

SAS

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