Circulating concentrations of soluble leptin receptor: influence of menstrual cycle and diet therapy.

Nutrition
Hiroyuki ShimizuMasatomo Mori

Abstract

Concentrations of the soluble leptin receptor (sOB-R) may be related to leptin resistance in obesity. We measured sOB-R concentrations in serum in 103 non-diabetic Japanese men and women. All subjects were grouped according to body mass index (BMI; in kg/m(2)). Serum sOB-R concentrations did not differ significantly between normal-weight (18.5 < or = BMI < 25.0) men and women, but were significantly higher in underweight subjects (BMI < 18.5) than in normal-weight subjects. In contrast, overweight (25 < or = BMI < 30) and obese (30 < or = BMI < 35.0, 35.0 < or = BMI < 40, and BMI > or = 40) subjects had significantly lower sOB-R concentrations than did normal-weight subjects. Serum sOB-R concentrations were inversely correlated with BMI and serum immunoreactive leptin concentrations. Very low-energy diet therapy for 4 wk significantly lowered serum immunoreactive leptin concentrations but did not significantly affect serum sOB-R concentrations. Serum sOB-R concentrations did not change significantly during the menstrual cycle. Our results showed that serum sOB-R concentrations decrease with increasing BMI and that sex hormones likely do not affect serum sOB-R concentrations in non-pregnant women. The reduction in serum sOB-R co...Continue Reading

References

Oct 1, 1995·The Journal of Clinical Investigation·D S WeigleJ L Kuijper
Feb 1, 1996·The New England Journal of Medicine·R V ConsidineT L Bauer
Jul 1, 1997·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·H ShimizuM Mori
Aug 1, 1997·The Journal of Endocrinology·H ShimizuM Mori
Dec 31, 1997·The Journal of Biological Chemistry·O GavrilovaM Reitman
Dec 5, 2000·The Journal of Biological Chemistry·L HuangC Li
Feb 24, 2001·BJOG : an International Journal of Obstetrics and Gynaecology·S SchulzW Weise
May 15, 2001·Biochemical and Biophysical Research Communications·A LammertJ Kratzsch

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Citations

Jul 6, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·T ReinehrW Andler
Oct 21, 2006·Endocrine Journal·Hiroyuki ShimizuMasatomo Mori
Feb 11, 2014·Irish Journal of Medical Science·G TianD Zhou
Jun 20, 2013·Clinical and Experimental Dermatology·K-J ZhuY-M Fan
Jul 17, 2015·International Journal of Endocrinology·Nasser M Rizk, Elham Sharif
May 2, 2006·Fertility and Sterility·Renato Pasquali
Apr 12, 2013·Journal of the Science of Food and Agriculture·Tânia G AlbuquerquePaul Finglas
Jun 9, 2004·Annals of Medicine·Tarja Saaresranta, Olli Polo

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