Circulating cytokines and gastrin levels in asymptomatic subjects infected by Helicobacter pylori (H. pylori)

Immunopharmacology and Immunotoxicology
F RussoA Di Leo

Abstract

The pathophysiology of hypergastrinemia in H. pylori infection has been largely investigated and different reports clearly show that the infected antrum has a marked inflammatory response with a suggestive local production of cytokines. Notwithstanding, a few data are available on the circulating levels of cytokines and gastrin in the asymptomatic people carrying H. pylori infection. Thus, aim of the study was to evaluate circulating proinflammatory cytokines [Interleukin (IL)-8, Interleukin (IL)-10, Interferon (IFN)-gamma, and Tumor Necrosis Factor (TNF)-alpha] and gastrin levels in H. pylori positive asymptomatic subjects vs. H. pylori negative ones. To this end, thirty healthy volunteers with no digestive symptoms or systemic disease were enrolled and H. pylori infection was identified by a 13C-urea breath test. Plasma levels of gastrin were determined using the RIA kit whereas IL-8, TNF-alpha, IL-10, and IFN-gamma levels in serum were measured with a solid-phase ELISA. Fifteen infected people showed significantly higher gastrin and TNF-alpha levels than uninfected subjects. On the contrary, IL-8 levels were significantly higher in the uninfected subjects than in H. pylori positive ones (P < 0.0422). IFN-gamma and IL-10 circ...Continue Reading

References

Nov 1, 1990·Gut·Y DenizotJ Benveniste
Dec 1, 1993·Gastroenterology·M MurakamiT Kita
Apr 1, 1996·Alimentary Pharmacology & Therapeutics·W L Peterson
Aug 1, 1997·European Journal of Gastroenterology & Hepatology·I L Beales, J Calam
Oct 23, 1997·Clinical Microbiology Reviews·J H CurfsJ A Hoogkamp-Korstanje
Dec 12, 1997·Gastroenterology·D R Cave
Sep 3, 1998·European Journal of Clinical Investigation·F S Lehmann, G A Stalder
Nov 24, 1998·Infection and Immunity·C LindholmA M Svennerholm
Apr 21, 1999·Alimentary Pharmacology & Therapeutics·P Ernst
Dec 10, 1999·Immunopharmacology and Immunotoxicology·A Di LeoE Jirillo

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Citations

Nov 7, 2003·Current Gastroenterology Reports·Hanchen LiJeanMarie Houghton
May 2, 2002·Journal of Gastroenterology and Hepatology·JeanMarie HoughtonTimothy C Wang
Sep 24, 2005·Digestion·Yuji NaitoHidekazu Suzuki
Mar 28, 2006·The Tohoku Journal of Experimental Medicine·Zhao Jian JunMasatomo Mori
Aug 10, 2004·Alimentary Pharmacology & Therapeutics·Y KondoM Itoh
Jul 21, 2006·Skinmed·Ibrahim H Galadari, Mohamed Omar Sheriff
Mar 1, 2005·Respiratory Medicine·Anastasios RoussosKonstantinos Gourgoulianis
Jun 1, 2017·Respiratory Research·Seung Won RaUNKNOWN Canadian Respiratory Research Network
Jan 23, 2016·European Heart Journal. Acute Cardiovascular Care·Giampaolo NiccoliFilippo Crea
Dec 18, 2012·European Journal of Gastroenterology & Hepatology·Xiaoying ZhouGuoxin Zhang
Mar 15, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yu-Lin SuLu-Ping Chow
Mar 10, 2007·International Journal of Immunopathology and Pharmacology·G Di BonaventuraM Neri
Jan 1, 2003·World Journal of Gastroenterology : WJG·Anastasios RoussosKonstantinos I Gourgoulianis
May 4, 2021·International Journal of General Medicine·Yoshitaka FurutoYuko Shibuya

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