Circulating Cytokines Associated with Poor Pregnancy Outcomes in Beninese Exposed to Infection with Plasmodium falciparum.

Infection and Immunity
Tatiana HountohotegbeAdrian J F Luty

Abstract

Malaria during pregnancy is a major cause of maternal morbidity as well as fetal and neonatal mortality. Previous studies, including our own, suggested that placental and peripheral cytokine and chemokine levels measured at delivery can be used as biomarkers for pregnancy outcomes. However, the timing of malaria infection during pregnancy matters, and these studies do not address the effect of different cytokines in peripheral blood plasma samples taken at early and midpregnancy and at delivery. Here, we aimed to investigate whether peripheral plasma cytokine levels were associated with pregnancy outcomes in a cohort of 400 Beninese pregnant women. Using a high-sensitivity cytometry-based method, we quantified the levels of interleukin-4 (IL-4), IL-5, IL-10, IL-12p70, and gamma interferon (IFN-γ) in peripheral plasma samples taken at two time points during pregnancy and at delivery in various groups of pregnant women identified with Plasmodium falciparum infection, with anemia, with preterm births, or giving birth to babies who are small for their gestational age. We found that, consistently at all time points, elevated levels of IL-10 were strongly and significantly associated with P. falciparum infection, while the levels of ...Continue Reading

References

Jul 1, 1991·Transactions of the Royal Society of Tropical Medicine and Hygiene·F NostenN J White
Feb 12, 1983·British Medical Journal·G H Rée
Apr 27, 1999·Immunology Letters·A W Taylor-Robinson, E C Smith
Nov 24, 1999·The Journal of Infectious Diseases·A M MoormannS R Meshnick
Jun 17, 2000·Infection and Immunity·A J LutyP G Kremsner
Jul 18, 2000·European Journal of Immunology·A JossC A Akdis
Mar 13, 2001·Annual Review of Immunology·K W MooreA O'Garra
Mar 28, 2002·Cellular and Molecular Life Sciences : CMLS·J G Beeson, G V Brown
Feb 4, 2003·Nature Reviews. Immunology·Giorgio Trinchieri
May 17, 2003·The Journal of Infectious Diseases·Robert D NewmanMonica E Parise
Nov 4, 2005·Current Topics in Microbiology and Immunology·J G Beeson, P E Duffy
Jan 9, 2007·Reproductive Biomedicine Online·Antonis Makrigiannakis, Vassilis Minas
Jan 26, 2007·The Lancet Infectious Diseases·Meghna DesaiRobert D Newman
Jan 31, 2008·Malaria Journal·Edward R KabyemelaPatrick E Duffy
Feb 13, 2008·Journal of Neuroendocrinology·N M Orsi, R M Tribe
Feb 24, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marilyn HalonenAnne L Wright
Dec 30, 2009·European Journal of Immunology·Katie L FlanaganSarah Rowland-Jones
Mar 6, 2010·Multiple Sclerosis : Clinical and Laboratory Research·M ComabellaJd Lünemann
May 12, 2010·American Journal of Reproductive Immunology : AJRI·Shigeru SaitoMika Ito
Mar 16, 2011·Annals of the New York Academy of Sciences·Gil MorSeth Guller
Apr 2, 2011·Malaria Journal·Bich-Tram HuynhMichel Cot
Aug 5, 2011·The American Journal of Tropical Medicine and Hygiene·Bich-Tram HuynhMichel Cot
Nov 24, 2011·Clinical & Developmental Immunology·Raj RaghupathyFawaz Azizieh
Oct 12, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michal FriedPatrick E Duffy
Feb 6, 2018·The Lancet Infectious Diseases·Stephen J RogersonAnna M van Eijk

❮ Previous
Next ❯

Citations

Aug 12, 2020·American Journal of Reproductive Immunology : AJRI·Erica ProchaskaIrina Burd
Jan 5, 2021·Frontiers in Immunology·Madeleine C Wiebe, Stephanie K Yanow

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.