Circulating D-dimer levels are better predictors of overall survival and disease progression than carcinoembryonic antigen levels in patients with metastatic colorectal carcinoma

Cancer
Kimberly BlackwellCharles Greenberg

Abstract

Fibrin formation is required for tumor angiogenesis, metastasis, and invasion. D-dimer, a fibrin degradation product, is produced when crosslinked fibrin is degraded by plasmin. The current study prospectively examined D-dimer levels in patients with metastatic colorectal carcinoma treated in a Phase II randomized trial comparing bevacizumab (Avastin, Genentech, South San Francisco, CA) plus 5-fluorouracil/leucovorin (5-FU/LV) with 5-FU/LV alone. At least one circulating D-dimer level was evaluable in 98 of the 104 previously untreated patients with metastatic colorectal carcinoma in the current trial. Plasma D-dimer levels were determined using a quantitative immunoassay kit at enrollment, before each treatment, and at the time of trial completion or disease progression. At trial enrollment, 86 of 104 patients (88%) had elevated D-dimer levels (> 20 ng/mL), and 86 of 102 patients (84%) had elevated carcinoembryonic antigen (CEA) levels (> 3 ng/mL). Baseline D-dimer levels were correlated with the following baseline characteristics: CEA (Pearson coefficient, 0.31; P = 0.002), albumin levels (Pearson coefficient, -0.32; P = 0.002), tumor burden (Pearson coefficient, 0.30; P = 0.003), and number of metastatic sites (Pearson coeff...Continue Reading

References

Jul 1, 1991·Seminars in Thrombosis and Hemostasis·T Wajima
Jan 1, 1991·Journal of Cancer Research and Clinical Oncology·C G Mitter, C C Zielinski
Nov 1, 1993·The British Journal of Surgery·C M EdwardsP K Donnelly
Apr 1, 1993·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·R SeitzK Havemann
Jan 1, 1995·International Journal of Clinical & Laboratory Research·P MontemurroN Semeraro
Jan 1, 1996·Seminars in Thrombosis and Hemostasis·W R Bell
Mar 7, 2001·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·S J PaveyN A Marsh
Jun 13, 2001·The European Respiratory Journal·D FerrignoI Ricca
Nov 1, 2001·Neoplasia : an International Journal for Oncology Research·M Z WojtukiewiczJ Rak
May 7, 2002·Molecular Biotechnology·Vincenzo ChiarugLucia Magnelli
May 8, 2002·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·M KohliC S Zent
Nov 28, 2002·British Journal of Cancer·R SalgadoL Y Dirix
Nov 29, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Steven R Pirie-Shepherd
Dec 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Fairooz KabbinavarEmily Bergsland

❮ Previous
Next ❯

Citations

Jan 15, 2008·Cancer Immunology, Immunotherapy : CII·Takuya OsadaMichael A Morse
May 24, 2011·Cancer Chemotherapy and Pharmacology·Søren Astrup Jensen, Jens Benn Sørensen
Mar 31, 2007·Journal of Thrombosis and Thrombolysis·Massimo FranchiniGiuseppe Lippi
Jun 15, 2013·Journal of Gastrointestinal Cancer·Faruk TasDerya Duranyildiz
Sep 9, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Roland von KänelIgor Grant
Jun 10, 2011·American Journal of Clinical Oncology·Sean D RajSaroj Vadhan-Raj
Sep 13, 2006·Gut·J HeidemannT Kucharzik
Nov 3, 2012·Therapeutic Advances in Medical Oncology·Axel Grothey, Carmen Allegra
Mar 1, 2007·Neuro-oncology·Ralph SimanekChristine Marosi
Jul 8, 2010·Clinical Chemistry and Laboratory Medicine : CCLM·Cristina VassalleMaria Grazia Andreassi
Oct 23, 2008·Rinshō shinkeigaku = Clinical neurology·Yasuyuki Ito, Yoichiro Hashimoto
Feb 6, 2014·Journal of Geriatric Oncology·Athanasios G PallisHans Wildiers
Feb 28, 2014·TheScientificWorldJournal·Bohdan KadlecJiri Jarkovsky
Sep 5, 2014·BMC Pharmacology & Toxicology·Anne PolkDorte L Nielsen
Jul 6, 2014·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·L-P GeL-R Zhu
May 12, 2007·Wiener klinische Wochenschrift·Lisa PleyerRichard Greil
Oct 2, 2012·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Gurkan TelliogluEren Berber
Dec 4, 2013·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Yi-Jen GuoYi-Chu Liao
Jul 18, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·L-R ZhuX-P Tang
Jul 3, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·P P ZhangK Li
May 15, 2008·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Y TomimaruS Imaoka
May 17, 2013·Journal of Surgical Oncology·Dongmei DiaoChengxue Dang
Aug 10, 2013·Cancer Medicine·Hope E UronisHerbert I Hurwitz
Mar 27, 2016·Laboratory Medicine·Roger S RileyRichard A McPherson
Dec 27, 2005·Journal of the American College of Surgeons·Yoshito TomimaruShingi Imaoka
Apr 17, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Kohei NakamuraSatoru Kyo
Apr 16, 2013·International Journal of Radiation Oncology, Biology, Physics·Joseph M Herman, Charles R Thomas
Oct 28, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Ya-Nan ManXiong-Zhi Wu
Sep 22, 2016·Gastroenterology Research and Practice·Kemal TekeşinVeli Melih Kara
Apr 15, 2010·Journal of Immunoassay & Immunochemistry·Andrea L Small-Howard, Holden Harris

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.