Circulating DNAs, a Marker of Neutrophil Extracellular Traposis and Cancer-Related Stroke: The OASIS-Cancer Study

Stroke; a Journal of Cerebral Circulation
Oh Young BangMyung-Ju Ahn

Abstract

Background and Purpose- The role of circulating neutrophil extracellular traps (NETs) in cancer-related stroke is unknown. Methods- We conducted a prospective cohort study to test whether NETs are increased in cancer-related stroke and whether elevated NETs levels are associated with coagulopathy, assessed using D-dimer levels (≥2 μg/mL). Plasma DNA and nucleosome were assessed as NET-specific biomarkers. Results- In total, 138 patients were recruited; 38 patients had cancer-related stroke (active cancer and acute cryptogenic embolic stroke), 33 patients were healthy-controls, 27 patients were cancer-controls (active cancer but no stroke), and 40 patients were stroke-controls (acute ischemic stroke but no cancer). Plasma DNA and nucleosome levels were significantly elevated in cancer-related stroke patients than in healthy-controls (P<0.05). These levels were correlated with the D-dimer levels (P<0.01). In multiple regression analyses, increased plasma DNA levels were associated with cancer-related stroke (odds ratio=11.65 for highest quartile; 95% CI, 3.199-42.46) and D-dimer levels of ≥2 μg/mL (odds ratio=19.09 for highest quartile; 95% CI, 4.143-87.95) after adjusting for possible confounders. Conclusions- Increased circulat...Continue Reading

References

Feb 21, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Tarek Sousou, Alok A Khorana
Feb 13, 2010·Stroke; a Journal of Cerebral Circulation·Seon Gyeong KimOh Young Bang
Jul 25, 2012·Proceedings of the National Academy of Sciences of the United States of America·Mélanie DemersDenisa D Wagner
Sep 18, 2012·PloS One·Suk Jae KimOh Young Bang
Oct 30, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Maurits L van MontfoortSacha Zeerleder
Mar 5, 2014·Seminars in Thrombosis and Hemostasis·Melanie Demers, Denisa D Wagner
Nov 25, 2016·Thrombosis and Haemostasis·Cihan AyAlexander T Cohen
Jul 12, 2017·Annals of Neurology·Elodie LaridanSimon F De Meyer
Apr 4, 2018·Stroke; a Journal of Cerebral Circulation·Jong-Won ChungOh Young Bang
Jan 12, 2019·Seminars in Thrombosis and Hemostasis·Elodie LaridanSimon F De Meyer

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Citations

Feb 7, 2020·Journal of Stroke·Oh Young BangUNKNOWN OASIS-Cancer Study Investigators
Apr 28, 2020·The Journal of International Medical Research·Xuemei QuanZhijian Liang
Sep 25, 2020·Journal of Leukocyte Biology·Wang LongHelong Dai
Jan 29, 2021·Stroke; a Journal of Cerebral Circulation·Babak B NaviLisa M DeAngelis
May 25, 2021·Annals of Neurology·Babak B NaviLisa M DeAngelis
May 21, 2021·Thrombosis Research·Carolina B S VáradyTainá Gomes
Jul 20, 2021·Seminars in Cancer Biology·Leonardo CristinzianoMaria Rosaria Galdiero
Jul 25, 2021·International Journal of Molecular Sciences·Nicole SteffensenNicole de Buhr
Aug 10, 2021·Disease Markers·Astrid ObermayerWalter Stoiber
Oct 15, 2021·Cardiovascular Research·Andres HidalgoCarlos Silvestre-Roig
Dec 3, 2021·Current Opinion in Hematology·Ofir Wolach, Kimberly Martinod

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