Circulating E-selectin and tumor necrosis factor-alpha in extraarticular involvement and joint disease activity in rheumatoid arthritis

Rheumatology International
Esther G Corona-SanchezJorge I Gamez-Nava


In this cross-sectional study, we assessed the relationship between circulating TNF-alpha and E-selectin (sE-selectin) with extraarticular involvement and severity of joint disease in RA. We compared 56 patients who had RA and extraarticular involvement (ExRA) with a group of 84 patients with only articular involvement (non-ExRA). ExRA had higher circulating TNF-alpha than non-ExRA (32 +/- 9 vs. 28 +/- 6 pg/mL, P = 0.002). sE-selectin levels did not differ between both groups. sE-selectin correlated with tender joint count (rho = 0.19, P = 0.03), morning stiffness (rho = 0.19, P = 0.03), severity of pain (rho = 0.21, P = 0.02), disease activity (assessed by the patient) (rho = 0.21, P = 0.02), HAQ-DI (rho = 0.29, P = 0.004), and rheumatoid factor titers (rho = 0.31, P = <0.001). Circulating TNF-alpha had no correlation with sE-selectin or disease activity. We concluded that sE-selectin correlated with severity of joint disease, further follow-up studies should evaluate if sE-selectin is useful as prognosis marker for progression of articular damage.


Jul 15, 2009·Clinical Rheumatology·Licia Maria Henrique da MotaJozélio Freire de Carvalho
Jul 8, 2011·PM & R : the Journal of Injury, Function, and Rehabilitation·Wan Huang, Gwendolyn Sowa
May 6, 2011·Scandinavian Journal of Rheumatology. Supplement·M Cutolo


May 27, 1996·Journal of Immunological Methods·A MeagerA Mire-Sluis
Aug 26, 1999·Rheumatology·C TuressonU Bergström
Aug 30, 2000·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·G VallienD N Granger
Nov 30, 2000·Arthritis Research·Z Szekanecz, A E Koch
Mar 22, 2001·The New England Journal of Medicine·E H Choy, G S Panayi
Feb 7, 2002·Annals of the Rheumatic Diseases·A KuulialaM Leirisalo-Repo
Apr 16, 2003·Annals of the Rheumatic Diseases·A E VoskuylF C Breedveld
May 16, 2003·Nature·Gary S Firestein
Aug 12, 2003·Arthritis and Rheumatism·Karl EgererGerd-Rüdiger Burmester

Related Concepts

Tumor Necrosis Factor-alpha
Severity of Illness Index
Incidence Studies
Rheumatoid Arthritis
SELE gene
TNF gene

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.