Circulating endothelial progenitor cells and endothelial cells in moyamoya disease

Brain and Behavior
Xiang-Yang BaoLian Duan

Abstract

There is no well-recognized biomarker for accurately predicting outcome in the presence of moyamoya disease (MMD), a progressive occlusive cerebrovascular disease of the internal carotid arteries or their branches. The aim of this study was to investigate the presence of endothelial progenitor cells (EPCs) and circulating endothelial cells (CECs) in MMD and correlate the findings with clinical features. Patients with MMD (n = 66) were compared with healthy controls (n = 81). Blood samples were obtained from an antecubital vein and analyzed using flow cytometry. EPCs were defined as CD31+ CD45dim CD34br CD133+ and CECs as CD31br CD45- CD34dim CD133- . Univariate and multivariate linear regression analyses were carried out. The CEC counts were significantly higher in the patients than in the controls (p = 0.008). In multivariate analysis, EPC counts were independently associated with age of patients with MMD (p = 0.049) and CEC counts were independently negatively associated with concomitant disease such as hypertension, diabetes mellitus, and coronary heart disease (p = 0.034). This is the first study to investigate the presence of CECs in the plasma of patients with MMD, and the amount of CECs was negatively correlated with con...Continue Reading

References

Oct 19, 2000·Neuropathology : Official Journal of the Japanese Society of Neuropathology·M FukuiK Ikezaki
Nov 10, 2000·European Journal of Haematology·F Dignat-George, J Sampol
Jun 22, 2002·Progress in Cardiovascular Diseases·James T Willerson
Jan 25, 2003·Blood·John D BelcherGregory M Vercellotti
Jul 17, 2003·Transplantation·Alexander WoywodtMarion Haubitz
Oct 2, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mehmet KoçMark S Segal
Jun 17, 2004·Circulation·Jean Davignon, Peter Ganz
Jan 22, 2005·Annual Review of Medicine·Aarif Y Khakoo, Toren Finkel
Jan 26, 2005·Cytometry. Part B, Clinical Cytometry·Sameena S KhanJ Philip McCoy
Apr 14, 2006·Neoplasia : an International Journal for Oncology Research·P K Y GoonA D Blann
Jul 14, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Uta ErdbrueggerAlexander Woywodt
Oct 13, 2006·Nature Reviews. Cancer·Francesco BertoliniRobert S Kerbel
Jan 31, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Tomoyuki YoshiharaHiroaki Naritomi
Jul 10, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Keun-Hwa JungJae-Kyu Roh
Dec 11, 2008·Journal of Cellular and Molecular Medicine·Frank TimmermansJamie Case
Dec 20, 2008·Stroke; a Journal of Cerebral Circulation·Neysan RafatPeter Vajkoczy
Oct 25, 2013·International Journal of Medical Sciences·Aline M AlessioJoyce M Annichino-Bizzacchi
Mar 6, 2015·Neurologia Medico-chirurgica·Miki Fujimura, Teiji Tominaga
Jul 17, 2015·Journal of Korean Neurosurgical Society·Ji Yeoun LeeKyu-Chang Wang
Feb 6, 2016·Journal of Stroke·Oh Young BangSeung-Ki Kim
Feb 6, 2016·Journal of Stroke·Tackeun KimWon-Sang Cho
Feb 11, 2016·Current Medicinal Chemistry·Gloria BediniAnna Bersano
Jul 28, 2016·International Journal of Stroke : Official Journal of the International Stroke Society·Oh Young BangGyeong Joon Moon

❮ Previous
Next ❯

Citations

Aug 17, 2020·International Journal of Molecular Sciences·Francesca TinelliLaura Gatti

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry
PCA

Software Mentioned

FlowJo
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.