Circulating endothelial progenitor cells in obese children and adolescents

Jornal de pediatria
António PiresRaquel Seiça

Abstract

This study aimed to investigate the relationship between circulating endothelial progenitor cell count and endothelial activation in a pediatric population with obesity. Observational and transversal study, including 120 children and adolescents with primary obesity of both sexes, aged 6-17 years, who were recruited at this Cardiovascular Risk Clinic. The control group was made up of 41 children and adolescents with normal body mass index. The variables analyzed were: age, gender, body mass index, systolic and diastolic blood pressure, high-sensitivity C-reactive protein, lipid profile, leptin, adiponectin, homeostasis model assessment-insulin resistance, monocyte chemoattractant protein-1, E-selectin, asymmetric dimethylarginine and circulating progenitor endothelial cell count. Insulin resistance was correlated to asymmetric dimethylarginine (ρ=0.340; p=0.003), which was directly, but weakly correlated to E-selectin (ρ=0.252; p=0.046). High sensitivity C-reactive protein was not found to be correlated to markers of endothelial activation. Systolic blood pressure was directly correlated to body mass index (ρ=0.471; p<0.001) and the homeostasis model assessment-insulin resistance (ρ=0.230; p=0.012), and inversely correlated to ...Continue Reading

References

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Citations

Feb 2, 2019·Diabetes/metabolism Research and Reviews·Howard Chong Huat HoRaffaella Buzzetti
Feb 2, 2018·PloS One·Evelyn Li Min TaiIsmail Shatriah
Apr 16, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Anurag MehtaArshed A Quyyumi

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