Circulating Epithelial Cell Characterization and Correlation with Remission and Survival in Patients with Thyroid Cancer

Thyroid : Official Journal of the American Thyroid Association
Jen-Der LinChing-Ping Tseng

Abstract

Thyroid cancer is the most common endocrine tumor and generally has relatively good clinical outcomes. However, 15-20% of patients ultimately develop recurrence or disease-related death. The appropriate prognostic factors for thyroid cancer are still elusive. This study evaluated whether the number of circulating tumor cells/circulating epithelial cells (CECs) expressing either epithelial cell adhesion molecule (EpCAM), podoplanin (PDPN), or thyrotropin receptor (TSHR) is related to remission and disease-specific mortality (DSM) of patients with thyroid cancer. Blood samples were collected from patients (n = 128) after thyroidectomy or radioactive iodide therapy. CECs were enriched by lysis of red blood cells and depletion of leukocytes. Subtyping and quantification of the enriched cells were performed with immunofluorescence staining using antibodies against EpCAM, TSHR, and PDPN, respectively. Whether the number of a specific subtype of CECs is related to remission and DSM of patients was determined by univariate and multivariate analyses. The EpCAM+-CECs, TSHR+-CECs, and PDPN+-CECs counts for patients in the non-remission group (n = 43) were significantly higher when compared to the remission group (n = 85; p < 0.001). Recei...Continue Reading

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Citations

Nov 19, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Peng-Xiang WangXin-Rong Yang
Apr 11, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ganglei LiJian Shen
Jul 23, 2021·International Journal of General Medicine·Mou-Chun GongFei-Hua Chen

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Methods Mentioned

BETA
blood drawing
transfection
fluorescence microscopy
dissection
blood collection
blood draw

Software Mentioned

PowerMag
CellSearch
IN Analyzer 1000

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