Circulating Epstein-Barr virus microRNAs BART7-3p and BART13-3p as novel biomarkers in nasopharyngeal carcinoma

Cancer Science
Tianzhu LuJianji Pan

Abstract

EBV BamHI A rightward transcripts (BART) encode microRNAs (EBV-miR-BARTs) abnormally highly expressed in Nasopharyngeal carcinoma (NPC). This study aims to investigate the diagnostic and prognostic performance of miR-BART7-3p and miR-BART13-3p. Plasma levels of EBV DNA, miR-BART7-3p, and miR-BART13-3p were examined by quantitative PCR in 483 treatment-naïve NPC patients and 243 controls without NPC. The prognostic performance was examined by comparing plasma levels with rates of distant metastasis during follow-up. The area under the receiver operating characteristic curve for diagnosing NPC was 0.926 for EBV DNA, 0.964 for plasma miR-BART7-3p, 0.973 for miR-BART13-3p, and 0.997 for all three indices. Among 465 NPC patients without distant metastasis, the above-median miR-BART7-3p and EBV-DNA were independent risk for shorter distant metastasis-free survival (DMFS) (HR=2.94, 95%CI: 1.44-5.97, p=0.003; HR=2.27, 95%CI:1.26-4.10, p=0.006) in multivariate Cox regression. EBV DNA, miR-BART7-3p, and miR-BART13-3p after radiotherapy were detectable in 28.6%, 17.6%, and 54.7% of patients, respectively. In multivariate Cox regression, detectable miR-BART7-3p and EBV-DNA were independent risks for shorter DMFS (HR=4.13, 95%CI: 1.89-9.01,...Continue Reading

References

Jun 11, 2004·The New England Journal of Medicine·Jin-Ching LinRong-San Jiang
Aug 18, 2005·British Journal of Cancer·L M McShaneUNKNOWN Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics
Dec 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sing-fai LeungAnthony T C Chan
Mar 18, 2011·Genetic Testing and Molecular Biomarkers·Yu LiuLishi Zhang
Mar 6, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Quynh-Thu LeK C Allen Chan
Feb 25, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Shaojun LinJiade Jay Lu
Sep 13, 2014·International Journal of Cancer. Journal International Du Cancer·Gaohong ZhangHonglin Chen
Sep 10, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anne W M LeeAnthony T C Chan
Apr 29, 2016·Chinese Clinical Oncology·Sherwood Y H FungKwan Chee Allen Chan
Nov 4, 2016·Nature Reviews. Cancer·Lawrence S YoungPaul G Murray
Apr 5, 2017·Journal of the National Cancer Institute·Kelly Y KimBarbara A Conley
Aug 10, 2017·The New England Journal of Medicine·K C Allen ChanY M Dennis Lo
May 16, 2018·Proceedings of the National Academy of Sciences of the United States of America·W K Jacky LamY M Dennis Lo
Jul 11, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anthony T C ChanY M Dennis Lo
Sep 14, 2018·Journal of Virology·Xiang ZhengJian Ma
Nov 10, 2018·International Journal of Cancer. Journal International Du Cancer·Octavia RamayantiDirk Michiel Pegtel
Jun 11, 2019·Lancet·Yu-Pei ChenJun Ma
Aug 31, 2019·International Journal of Cancer. Journal International Du Cancer·Lu Ping TanUNKNOWN Malaysian Nasopharyngeal Carcinoma Study Group

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
nucleic acid extraction

Software Mentioned

GraphPad Prism
R Foundation for Statistical
R
7500
GraphPad
SPSS
ViiA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.