Circulating Exosomal Gastric Cancer-Associated Long Noncoding RNA1 as a Biomarker for Early Detection and Monitoring Progression of Gastric Cancer: A Multiphase Study

JAMA Surgery
Xin GuoLin Chen

Abstract

The gastric cancer (GC)-associated long noncoding RNA1 (lncRNA-GC1) plays an important role in gastric carcinogenesis. However, exosomal lncRNA-GC1 and its potential role in GC are poorly understood. To evaluate the diagnostic value of circulating exosomal lncRNA-GC1 for early detection and monitoring progression of GC. We performed a multiphase investigation of circulating exosomal lncRNA-GC1 for early detection of GC involving consecutive patients with GC (n = 522), patients with gastric precancerous lesions (n = 85), and healthy donor individuals (HDs; n = 219) from December 2016 to February 2019 at Chinese People's Liberation Army General Hospital, China. LncRNA-GC1 was measured by reverse transcription-polymerase chain reaction by independent researchers who had no access to patients' information. Receiver operating characteristic curves were used to calculate diagnostic efficiency in comparison between lncRNA-GC1 and 3 traditional biomarkers (carcinoembryonic antigen [CEA], cancer antigen 72-4 [CA72-4], and CA19-9). Assessment of diagnostic efficiency on the basis of area under curve (AUC), specificity, and sensitivity. Of the 826 patients included in the study, 508 were men (61.5%), and the median age of all patients was...Continue Reading

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Citations

Oct 13, 2020·Journal of Cellular Physiology·Shenglong Li, Xiaohong Wang
Oct 31, 2020·Clinical and Experimental Medicine·Hong HuChangsheng Ye
Oct 27, 2020·Expert Review of Molecular Diagnostics·Esmat AbdiZahra Taherian-Esfahani
Mar 24, 2021·Journal for Immunotherapy of Cancer·Gaopeng LiBaofeng Yu
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Jul 27, 2021·Frontiers in Cell and Developmental Biology·Zihao ChenDong Wang
Jul 27, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hanyu ZhangMingxing Li
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Jan 5, 2022·Journal of Cellular and Molecular Medicine·Qiang Liu

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Methods Mentioned

BETA
biopsy
Assay

Software Mentioned

SPSS
GraphPad Prism

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