Circulating exosomal long noncoding RNA PRINS-First findings in monoclonal gammopathies

Hematological Oncology
L SedlarikovaS Sevcikova

Abstract

Multiple myeloma is the second most common hematological malignancy characterized by focal lesions of malignant plasma cells in the bone marrow. These lesions contain subclones that directly influence survival of patients. Bone marrow biopsies are single-site biopsies and thus cannot contain all information about the tumor. In contrast, liquid biopsies analyze circulating cells and molecules that are secreted from all sites of the tumor. Long noncoding RNA molecules are one class of these molecules. We performed a two-phase biomarker study investigating lncRNA expression profiles in exosomes of peripheral blood serum of newly diagnosed multiple myeloma (MM) patients, monoclonal gammopathy of undetermined significance (MGUS) patients in comparison with healthy donors (HD). Surprisingly, this analysis revealed dysregulation of only one exosomal lncRNA PRINS in MM vs HD. Overall, MM and MGUS patients were distinguished from HD with sensitivity of 84.9% and specificity of 83.3%. Our study suggests a possible diagnostic role for exosomal lncRNA PRINS in monoclonal gammopathies patients.

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Citations

Jan 27, 2019·Non-coding RNA·Romana ButovaRoman Hajek
Aug 27, 2019·Science and Technology of Advanced Materials·Tomofumi YamamotoTakahiro Ochiya
Apr 21, 2020·Journal of Clinical Laboratory Analysis·Dongming GuoJuntian Chen
May 10, 2020·Cells·Cristina P R XavierM Helena Vasconcelos
Jul 30, 2020·Endocrine Pathology·Oyewale ShiyanbolaRicardo V Lloyd
Oct 28, 2019·Experimental Hematology·Qingqing YinShaoqing Ju
Oct 30, 2020·International Journal of Nanomedicine·Victor C Kok, Cheng-Chia Yu
Apr 4, 2021·Genes·Dorian ForteLucia Catani
Aug 2, 2021·Journal of Pharmaceutical and Biomedical Analysis·Shashi RanjanPradyumna Kumar Mishra

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Methods Mentioned

BETA
biopsy
biopsies
ISS
transmission electron microscopy

Software Mentioned

7500 SDS
LIMMA
MedCalc
GraphPad Prism
SDS
SPSS
Bioconductor
R

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