PMID: 8582085Oct 1, 1995Paper

Circulating fragments of cytokeratin 19 in patients with head and neck squamous cell carcinoma

Clinical Otolaryngology and Allied Sciences
V BongersG B Snow

Abstract

In head and neck squamous cell carcinoma a reliable serum marker of carcinogenesis should be of predictive value for the development of recurrent disease or a second primary tumour. At the moment, such a tumour marker is not available. Recently, elevated levels of cytokeratin 19-fragments (Cyfra 21-1) have been detected in the serum of patients with lung cancer, in particular with squamous cell carcinoma. Cytokeratin 19 is an intermediate cell filament protein expressed in simple epithelia and their malignant counterparts. Therefore, in this prospective study, a standardized sandwich enzyme-linked immunosorbent assay for soluble cytokeratin 19 fragments was tested in the serum of 20 patients with a previously untreated head and neck squamous cell carcinoma. The results were compared with that of 20 control individuals. Our results showed significantly higher Cyfra 21-1 concentrations in the serum of patients with cancer (10.21 +/- 3.03 ng/ml) than the controls (7.2 +/- 2.63 ng/ml). After radical treatment the marker levels dropped significantly to 1.65 +/- 1.07 ng/ml. Cyfra 21-1 appears to be of value as a circulating tumour marker for head and neck squamous cell carcinoma especially in monitoring disease control.

Citations

Jan 19, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Rewa MalhotraBhawna Mahajan
Jan 22, 2008·Oral Oncology·Sharada S SawantMilind M Vaidya
Aug 22, 2015·World Journal of Surgical Oncology·Yin-Ping HsuShiang-Fu Huang
Oct 30, 1999·Clinical Otolaryngology and Allied Sciences·J J HomerN D Stafford
Nov 16, 2005·The Annals of Otology, Rhinology, and Laryngology·Philippe CéruseFrançois Disant
Feb 9, 2013·Polish Journal of Veterinary Sciences·A Kycko, M Reichert
Apr 15, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Stefan A RudhartStephan Hoch

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