PMID: 6510881Oct 1, 1984

Circulating HBsAg/IgM complexes in acute and chronic hepatitis B

A MuscaF Balsano


Complexes between HBsAg and IgM have recently been described in the sera of HBsAg carriers. A solid phase RIA for HBsAg/IgM complexes has been described. Fifteen patients with acute viral hepatitis type B, and 52 HBsAg chronic carriers were studied. Testing of serial sera in acute hepatitis patients revealed that HBsAg/IgM complexes disappeared (preceding HBsAg negativization and usually at the same time as seroconversion from "e" to "anti-e") with 4 weeks in all but one patient who became a chronic HBsAg carrier. In addition, HBsAg/IgM complexes were found in 48% of HBsAg chronic carriers, in 69% of CPH patients, but in only 20% of healthy carriers (p less than 0.005). Although complexes were detectable in 93% HBeAg positive chronic carriers, they were also frequently found in anti-HBe positive patients, but never in e/anti-e negative patients (p less than 0.001). HBsAg/IgM complexes seem to be of important prognostic and diagnostic value in acute and chronic hepatitis B.

Related Concepts

Immune complex
Hepatitis B
HBe Ag-2
Hepatitis B Surface Antigens

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.