Circulating Heat Shock Protein 70 Is a Novel Biomarker for Early Diagnosis of Lung Cancer

Disease Markers
Tielong TangJing Huang

Abstract

Heat shock protein 70 (HSP70) was a highly conserved protein which was significantly induced in response to cellular stresses. HSP70 played an important role in the pathogenesis of cancer which stabilized the production of large amount of oncogenic proteins and finally supported growth and survival of tumor. However, there was no report about the diagnosis of circulating HSP70 in lung cancer patients. In this study, a total of 297 participants (lung cancer: 197, healthy control: 100) were enrolled in the detection of circulating HSP70 level in plasma by ELISA assay. The results indicated that circulating HSP70 significantly decreased in lung cancer patients compared to healthy controls (P < 0.0001). Receiver operating characteristic (ROC) analysis showed that HSP70 (AUC: 82.2%, SN: 74.1%, SP: 80.0%) had higher diagnosis value than clinical existing biomarkers CEA (AUC: 80.1%, SN: 76.8%, SP: 67.3%) and CA 19-9 (AUC: 63.7%, SN: 64.2%, SP: 54.0%). In the analysis of early lung cancer patients, ROC results also revealed that HSP70 (AUC: 83.8%, SN: 71.2%, SP: 84.0%) have higher sensitivity, specificity, and AUC than CEA (AUC: 73.7%, SN: 73.2%, SP: 69.1%) and CA 19-9 (AUC: 61.5%, SN: 69.4%, SP: 53.4%). In analysis of specific histolo...Continue Reading

References

Sep 1, 1996·Japanese Journal of Cancer Research : Gann·M YanoG Asano
Nov 27, 2002·Surgical Oncology·P Iyengar, M-S Tsao
Mar 24, 2004·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Yukinori SakaoTsuyoshi Itoh
Sep 21, 2005·The Journal of Biological Chemistry·Adam R StankiewiczDick D Mosser
Feb 18, 2006·Trends in Biochemical Sciences·Stuart K CalderwoodDaniel R Ciocca
Dec 9, 2008·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Rafael MolinaXavier Filella
Jun 6, 2009·Nature Structural & Molecular Biology·F Ulrich Hartl, Manajit Hayer-Hartl
Jul 22, 2011·Nature·F Ulrich HartlManajit Hayer-Hartl
Mar 21, 2013·JAMA : the Journal of the American Medical Association·Phillip M Boiselle
Apr 9, 2013·Carcinogenesis·Maureen E Murphy
Mar 29, 2014·Oncotarget·Lei ZhangFaith E Davies
Jan 7, 2015·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
May 6, 2015·International Journal of Radiation Oncology, Biology, Physics·Cary OberijePhilippe Lambin
Oct 10, 2015·Oncotarget·Laura O'ReganAndrew M Fry
Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He
Feb 9, 2016·International Journal of Cancer. Journal International Du Cancer·Cun WangWenxin Qin
Jun 11, 2012·Lung Cancer : Targets and Therapy·Eloisa Jantus-LewintreCarlos Camps

❮ Previous
Next ❯

Citations

Nov 22, 2019·Frontiers in Molecular Biosciences·Kuldeep DhamaSunil Kumar Joshi
Jul 1, 2020·Journal of Extracellular Vesicles·Gaëtan ChanteloupJessica Gobbo
Apr 2, 2020·Cancer Biology & Therapy·Sonam Mittal, Maitreyi S Rajala
Dec 15, 2020·Critical Reviews in Food Science and Nutrition·Taslima Akter EvaJesus Simal-Gandara
Nov 11, 2020·Journal of Cellular Physiology·Mehdi A VostakolaeiJalal Abdolalizadeh
Aug 25, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shuxian YangLi Cao

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
Assay
X-ray

Software Mentioned

GraphPad Prism
SPSS16

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.