Circulating hematopoietic stem cells do not efficiently home to bone marrow during homeostasis

Experimental Hematology
Shannon L McKinney-Freeman, M A Goodell

Abstract

Hematopoietic stem cells (HSC), normally resident in bone marrow, can be detected in the murine and human circulation. It is thought that HSC move in and out of bone marrow daily and that returning HSC are generally equivalent to their bone marrow counterparts in phenotype and function. However, large numbers of mononuclear blood cells are required to rescue animals from lethal irradiation, indicating either that the prevalence of circulating HSC is low, or they are inherently deficient in their repopulating ability. Accordingly, recent data suggest that circulating HSC may be unable to stably engraft WBM under homeostatic conditions. The purpose of this study was to explore these dynamics in detail using parabiosis and bone marrow transplantation. The WBM and skeletal muscle HSC stem cell compartments of parabiosed CD45 congenic mice were analyzed functionally (via bone marrow transplantation) and phenotypically (via flow cytometry) for circulating stem cells at specific time points postparabiosis and after surgical separation. Surprisingly, we find that stem cells trafficking out of bone marrow and into the circulation do not stably return to bone marrow, although long-lived lymphoid precursors do stably re-engraft. Circulati...Continue Reading

References

Apr 1, 1986·The Journal of Experimental Medicine·P D ShahD A Rowley
Nov 25, 1967·Lancet·D W Barnes, J F Loutit
Jan 22, 1971·Science·K B McCredieE J Freireich
Jan 1, 1983·Vox Sanguinis·P Tippett
Mar 1, 1984·The Journal of Experimental Medicine·G Van Zant
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·G BrecherE P Cronkite
Apr 1, 1996·The Journal of Experimental Medicine·M A GoodellR C Mulligan
Dec 10, 1999·Proceedings of the National Academy of Sciences of the United States of America·K A JacksonM A Goodell
Dec 1, 2001·Science·D E WrightI L Weissman
Feb 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Shannon L McKinney-FreemanMargaret A Goodell
Apr 9, 2002·Experimental Hematology·Surasit IssarachaiThalia Papayannopoulou
Oct 16, 2002·The Journal of Cell Biology·Atsushi AsakuraMichael A Rudnicki
Sep 10, 2003·Experimental Hematology·Shannon L McKinney-FreemanMargaret A Goodell

❮ Previous
Next ❯

Citations

Nov 6, 2009·The Journal of Experimental Medicine·Deepta BhattacharyaIrving L Weissman
Feb 24, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Kun LuJames A Swenberg
May 4, 2011·Current Opinion in Hematology·Jonathan Hoggatt, Louis M Pelus
Nov 24, 2011·Cytotherapy·Sarah L Ellis, Susan K Nilsson
Feb 5, 2008·Current Problems in Cardiology·Annarosa LeriWilliam H Frishman
Aug 31, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ken KumagaiGeorge F Muschler
Oct 14, 2014·Journal of Tissue Engineering and Regenerative Medicine·Shinya YamasakiHiroaki Nakamura
Feb 24, 2005·Leukemia Research·Shannon L McKinney-Freeman
Aug 22, 2006·Trends in Immunology·Thomas Boehm, Conrad C Bleul
Mar 2, 2005·Developmental Cell·Christos GekasHanna K A Mikkola
Sep 27, 2005·Physiological Reviews·Annarosa LeriPiero Anversa
Sep 13, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kimie TanakaRyozo Nagai
Jun 26, 2020·Annual Review of Cell and Developmental Biology·Joseph N PucellaBoris Reizis
Oct 24, 2021·Experimental Hematology·Nicole Mende, Elisa Laurenti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.