Circulating HIV-Specific Interleukin-21(+)CD4(+) T Cells Represent Peripheral Tfh Cells with Antigen-Dependent Helper Functions

Immunity
Bruce T SchultzHendrik Streeck

Abstract

A central effort in HIV vaccine development is to generate protective broadly neutralizing antibodies, a process dependent on T follicular helper (Tfh) cells. The feasibility of using peripheral blood counterparts of lymph node Tfh cells to assess the immune response and the influence of viral and vaccine antigens on their helper functions remain obscure. We assessed circulating HIV-specific IL-21(+)CD4(+) T cells and showed transcriptional and phenotypic similarities to lymphoid Tfh cells, and hence representing peripheral Tfh (pTfh) cells. pTfh cells were functionally active and B cell helper quality differed depending on antigen specificity. Furthermore, we found higher frequency of pTfh cells in peripheral blood mononuclear cell specimens from the ALVAC+AIDSVAX (RV144) HIV vaccine trial associated with protective antibody responses compared to the non-protective DNA+Ad5 vaccine trial. Together, we identify IL-21(+)CD4(+) T cells as pTfh cells, implicating them as key populations in the generation of vaccine-evoked antibody responses.

References

Dec 6, 2000·The Journal of Experimental Medicine·P SchaerliB Moser
Nov 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·P SchaerliB Moser
Jul 10, 2002·Trends in Immunology·Bernhard MoserPius Loetscher
Nov 26, 2002·Science·Katsutoshi OzakiWarren J Leonard
Jan 20, 2005·The Journal of Experimental Medicine·Claire L LangrishDaniel J Cua
Mar 14, 2009·Nature Protocols·Hendrik StreeckBruce D Walker
May 9, 2009·Science·Heidi ElsaesserDavid G Brooks
Oct 22, 2009·The New England Journal of Medicine·Supachai Rerks-NgarmUNKNOWN MOPH-TAVEG Investigators
Mar 3, 2010·Annual Review of Immunology·Jinfang ZhuWilliam E Paul
Nov 26, 2010·Expert Review of Vaccines·Damien Z Soghoian, Hendrik Streeck
Feb 26, 2011·Immunity·Yoichiro IwakuraSusumu Nakae
Apr 8, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nina ChevalierCharles R Mackay
Jan 10, 2012·Annual Review of Immunology·Gabriel D Victora, Michel C Nussenzweig
Apr 6, 2012·The New England Journal of Medicine·Barton F HaynesJerome H Kim
Apr 17, 2012·Immunological Reviews·Mark J Shlomchik, Florian Weisel
Oct 23, 2012·Cell Host & Microbe·Dennis R BurtonRichard Wyatt
Feb 8, 2013·Nature Medicine·Hendrik StreeckShane Crotty
Mar 15, 2013·Science Translational Medicine·Salah-Eddine BentebibelHideki Ueno
May 3, 2013·Journal of Virology·Mohammed Ata Ur RasheedRafi Ahmed
Sep 14, 2013·Science·Florian KleinMichel C Nussenzweig
Oct 9, 2013·The New England Journal of Medicine·Scott M HammerUNKNOWN HVTN 505 Study Team
Feb 6, 2014·PLoS Pathogens·Kristin L BoswellRichard A Koup
Mar 5, 2014·Nature·Nicole A Doria-RoseJohn R Mascola
Mar 22, 2014·Science Translational Medicine·Nicole L YatesGeorgia D Tomaras
Apr 8, 2014·Trends in Immunology·Franco Pissani, Hendrik Streeck
May 15, 2015·Journal of Virology·Susan JohnsonHendrik Streeck

❮ Previous
Next ❯

Citations

Jan 21, 2016·Immunity·Ann Chahroudi, Guido Silvestri
Mar 8, 2016·Trends in Microbiology·Brodie Miles, Elizabeth Connick
Jul 9, 2016·Trends in Immunology·Yuan Tian, Allan J Zajac
Oct 18, 2016·Frontiers in Immunology·Mathieu F ChevalierLaurence Weiss
Aug 26, 2016·Current Opinion in HIV and AIDS·Hendrik Streeck
Jan 31, 2017·Immunological Reviews·Colin Havenar-DaughtonShane Crotty
Jan 31, 2017·Immunological Reviews·Persephone Borrow, M Anthony Moody
Apr 11, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cyril PlanchaisSophie Hüe
Jan 29, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lesley R de ArmasSavita Pahwa
May 5, 2017·Journal of Virology·Supranee BuranapraditkunHendrik Streeck
Jun 20, 2018·The Journal of Infectious Diseases·Kirk HaltaufderhydeAnuja Mathew
Feb 1, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pietro CrivelloStefan Heinrichs
Apr 12, 2019·Current Opinion in HIV and AIDS·Arnaud MorisLisa Chakrabarti
Jan 14, 2017·Frontiers in Immunology·Brodie MilesElizabeth Connick
Jun 24, 2017·The Journal of Experimental Medicine·Antje HeitM Juliana McElrath
Aug 23, 2017·Scientific Reports·Maximilian KoblischkeJudith H Aberle
Oct 11, 2017·Médecine sciences : M/S·Angeline RouersStéphanie Graff-Dubois
Mar 15, 2018·Frontiers in Immunology·Monica Vaccari, Genoveffa Franchini
Jun 28, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jennifer M DanShane Crotty
Nov 23, 2017·Frontiers in Immunology·Stéphane RodriguezPatricia Amé-Thomas
Nov 29, 2016·Frontiers in Immunology·Stéphanie Graff-DuboisArnaud Moris
May 6, 2017·Frontiers in Immunology·Francesca ChiodiAikaterini Nasi
Mar 8, 2017·Frontiers in Immunology·Félicien MoukambiJérôme Estaquier
Jun 21, 2018·Viruses·Julia Niessl, Daniel E Kaufmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.