Circulating human interleukin-8 as an indicator of cancer progression in a nude rat orthotopic human non-small cell lung carcinoma model

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Hillary J MillarEric Wickstrom

Abstract

Clinically relevant animal models of human cancer are necessary for the evaluation of putative therapeutics. We hypothesized that circulating human lung cancer-associated proteins would correlate with physiologic measurements from an orthotopic H460 human non-small cell lung carcinoma model that we developed in immunodeficient rats. Physiologic measurements and serum samples were collected over time. Serum interleukin-8 (IL-8), p53, vascular endothelial growth factor, and matrix metalloproteinase-9 were quantitated for correlation with physiologic measurements. Matrix metalloproteinase-9 and p53 were not significantly detectable. Circulating vascular endothelial growth factor was detected at high levels in some tumor-bearing animals. Human IL-8 was detectable in all tumor-bearing animals and correlated positively with markers of respiratory acidosis (pH, P = 0.012; TCO(2), P = 0.024; pCO(2), P = 0.007; and HCO(3)(-), P = 0.029) and with surface body temperature (P = 0.001) beginning on day 16 after implantation. IL-8 levels negatively correlated with survival (P < 0.001), indicating an association with tumor burden. Circulating human IL-8 might be a useful, clinically relevant circulating tumor protein marker due to its positiv...Continue Reading

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Citations

Nov 26, 2010·The Journal of Biological Chemistry·R Sean McNallyJenny P-Y Ting
Jul 25, 2009·American Journal of Respiratory and Critical Care Medicine·Carlo Sorrentino, Emma Di Carlo
Sep 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Imtiyaz Ahmad BhatZafar Amin Shah
Oct 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Xiao-Yun SongZhi-Dong Liu
Sep 1, 2015·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·S A AlmatroodiD S Pouniotis
Nov 15, 2020·Translational Oncology·Murali Mohan Sagar BallaBadri Narain Pandey

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