Circulating human papillomavirus DNA as a surveillance tool in head and neck squamous cell carcinoma: A systematic review and meta-analysis

Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
K K JensenC von Buchwald

Abstract

The incidence of human papillomavirus-induced (HPV+) head and neck squamous cell carcinoma (HNSCC), that is, especially oropharyngeal cancers (OPSCC), is increasing, and a significant proportion of patients encounter disease progression. A simple and sensitive test to identify patients with progression is an unmet need. To systematically review the literature and carry out a meta-analysis of studies, investigating circulating HPV-DNA as a biomarker for disease progression in patients with HNSCC. A systematic review and meta-analysis. PubMed, EMBASE and the Cochrane Library were systematically searched for articles published in English from January 1980 to November 2017. Search terms used were related to HPV, cancer sites, blood-based biomarkers and terms for specific use settings. Articles reviewed and selected by authors and data on study design, demographic variables, location, HPV status, number of pre-treatment blood tests, number of post-treatment blood tests, blood HPV status and number of recurrences and length of follow-up were extracted. A meta-analysis of HPV-DNA as a diagnostic test for recurrence by means of a hierarchical summary receiver operating curve (HSROC) model was performed. We identified 5 studies (n = 600...Continue Reading

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Citations

Jul 18, 2019·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·K ParameshwaranW D Rawlinson
Apr 1, 2020·Acta Oncologica·Amalie Hartvig PallChristian von Buchwald
Sep 25, 2020·British Journal of Cancer·Laura KellerKlaus Pantel
Sep 27, 2019·Frontiers in Oncology·Panagiota EconomopoulouAmanda Psyrri
Feb 10, 2021·Current Treatment Options in Oncology·Sarah M DermodyPaul L Swiecicki
May 18, 2020·International Journal of Radiation Oncology, Biology, Physics·Steven De MichinoScott V Bratman
Jul 11, 2021·Hematology/oncology Clinics of North America·Eleni M Rettig, Rosh K V Sethi

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