Circulating hypoxia marker carbonic anhydrase IX (CA9) in patients with hepatocellular carcinoma and patients with cirrhosis

PloS One
Fabian FinkelmeierOliver Waidmann

Abstract

Expression of carbonic anhydrase IX (CA9), an enzyme expressed in response to hypoxia, acidosis and oncogenic alterations, is reported to be a prognostic factor in HCC patients. Here we evaluated serum CA9 levels in HCC and cirrhosis patients. HCC and cirrhosis patients were prospectively recruited and CA9 levels were determined. CA9 levels were compared to stages of cirrhosis and HCC stages. The association of the CA9 levels and overall survival (OS) was assessed. Furthermore, immunohistochemical CA9 expression in HCC and cirrhosis was evaluated. 215 patients with HCC were included. The median serum CA9 concentration in patients with HCC was 370 pg/ml and significantly higher than in a healthy cohort. Patients with advanced cancer stages (BCLC and ALBI score) had hid significant higher levels of CA9 in the serum. HCC patients with high serum CA9 concentrations (>400 pg/ml) had an increased mortality risk (hazard ratio (HR) 1.690, 95% confidence interval (CI) 1.017-2.809, P = 0.043). Serum CA9 concentration in cirrhotic patients did not differ significantly from HCC patients. Higher CA9 levels in cirrhotic patients correlated with portal hypertension and esophageal varices. Patients with ethanol induced cirrhosis had the highes...Continue Reading

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Citations

Aug 28, 2019·International Journal of Molecular Sciences·Julián Piñeiro FernándezCliona O'Farrelly
Apr 24, 2019·British Journal of Cancer·Casper ReijnenJohanna M A Pijnenborg
Dec 4, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Ozen Ozensoy GulerClemente Capasso
Apr 9, 2020·Diagnostic Pathology·Dalia Rifaat Al-SharakyHala Said El-Rebey
Apr 27, 2021·Cancer Biomarkers : Section a of Disease Markers·Sanaa A El-BenhawyRabie Ramadan

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Methods Mentioned

BETA
surgical resection
ELISA

Software Mentioned

GraphPad Prism
SPSS
eSlide manager
GraphPad

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