Circulating IgA from acute stage of childhood Henoch-Schönlein purpura can enhance endothelial interleukin (IL)-8 production through MEK/ERK signalling pathway.

Clinical and Experimental Immunology
Y-H YangB-L Chiang

Abstract

Recently, sera from children with active Henoch-Schönlein purpura (HSP) have been found to enhance interleukin (IL)-8 production by human umbilical venous endothelial cells (HUVEC). To further determine the possible factor with the ability to enhance endothelial IL-8 production in sera from acute stage of HSP, 10 children with HSP at the acute stage and 10 healthy controls were enrolled. IgA antiendothelial cell antibodies (AECA) were detected by cell-based ELISA. Active sera with or without pretreatment with anti-human IgA antibody, sera of controls, and immunoglobulin A (IgA) derived from sera were used to stimulate the HUVEC. The ability of these factors to enhance endothelial IL-8 production was evaluated. Furthermore, signalling pathways were also assayed by different inhibitors, and confirmed by immunoblotting. Serum levels of IgA AECA in HPS patients at the acute stage were significantly higher than in controls (P < 0.001). The active sera could enhance endothelial IL-8 production (P = 0.004, compared with control sera), and the ability of these sera was mostly abolished when pretreated with fixed anti-human IgA antibody. The supernatant IL-8 levels of endothelial cells stimulated by IgA derived from acute stage of HSP w...Continue Reading

References

Oct 1, 1989·The Journal of Clinical Investigation·M BaggioliniS L Kunkel
Jul 1, 1983·International Journal of Dermatology·N P Wenner, B Safai
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·L Shapiro, C A Dinarello
May 1, 1997·International Journal of Dermatology·R BissonnetteJ Paradis
Dec 12, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·R CoppoF P Schena
Jan 1, 1997·Scandinavian Journal of Rheumatology·N BesbasA M Elnahas
Jul 27, 2001·Clinical and Experimental Immunology·A BordronP Youinou
Nov 12, 2002·Rheumatology International·Selim NalbantIsmail Hakki Kocer
Nov 19, 2002·Journal of Medical Virology·Chiou-Feng LinYee-Shin Lin
Sep 10, 2003·Current Opinion in Rheumatology·Susan Ballinger
Aug 10, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y TsujiT Sakai

❮ Previous
Next ❯

Citations

Jan 30, 2008·Clinical Reviews in Allergy & Immunology·Philippe Guilpain, Luc Mouthon
May 26, 2010·Rheumatology International·Ismail DursunMetin Kaya Gurgoze
Jun 4, 2011·Archives of Dermatological Research·Tao ChenTing Lai
Dec 20, 2011·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Mei-Chen TengBor-Luen Chiang
Apr 4, 2015·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Hsin-Hui YuBor-Luen Chiang
Nov 12, 2014·Journal of Clinical Laboratory Analysis·Ahmet Taner Elmas, Yilmaz Tabel
Jul 30, 2014·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Hsin-Hui YuBor-Luen Chiang
Jan 15, 2008·Autoimmunity Reviews·Yao-Hsu YangBor-Luen Chiang
Sep 21, 2011·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Hsiao-Yu JenYao-Hsu Yang
Jan 29, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Shuangyan LuoQianjin Lu
Dec 19, 2016·Autoimmunity Reviews·Paul LegendreLuc Mouthon
Dec 27, 2016·Frontiers in Immunology·Karolina A ZielińskaPhilippe E Van den Steen
Aug 4, 2018·Clinical Rheumatology·T KuretA Hočevar
Jun 27, 2014·Annals of Dermatology·Na CaoXiao-Yan Jiao
Jul 27, 2010·Coronary Artery Disease·Demosthenes G KatritsisHaralampos M Moutsopoulos
Jul 27, 2018·Current Rheumatology Reviews·Selcan DemirSeza Özen
Aug 5, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Xue ZhangHong Zhang
Jul 26, 2019·Journal of Pediatric Hematology/oncology·Zeynep C ÖzdemirÖzcan Bör
Apr 16, 2019·Frontiers in Immunology·Annelot Breedveld, Marjolein van Egmond
Jul 3, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hatice Adiguzel DundarSalih Kavukcu
Jan 16, 2021·ImmunoTargets and Therapy·Melissa Maria Johanna van Gool, Marjolein van Egmond
Dec 19, 2019·Journal of Pediatric Hematology/oncology·Zeynep C ÖzdemirÖzcan Bör
May 11, 2013·The International Journal of Artificial Organs·Lina ChenXiuying Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.