Circulating IL-33 level is associated with the progression of lung cancer

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Myung Shin KimChoon-Sik Park

Abstract

Interleukin (IL)-33 protects against infection and inflammation; however, few studies have explored the relevance of IL-33 in lung cancer patients. We evaluated relation of plasma IL-33 levels with development and progression of lung cancer. A total of 160 patients with lung cancer and 160 controls with normal lungs were enrolled. Plasma IL-33 levels were measured using a specific sandwich ELISA; these levels were followed-up in 18 patients who underwent surgery and in 14 patients treated with chemotherapy. Malignant lesions and normal lung tissues from 10 cancer patients were subjected to immunohistochemical staining for IL-33. IL-33 levels were significantly lower in cancer patients than normal controls (0.08 vs. 0.38 ng/mL, p=0.005). Among cancer patients, IL-33 decreased in a stage-dependent manner from 0.76 ng/mL in stage I patients to 0.25 ng/mL in those with stage II, 0.08 ng/mL in those with stage III, and 0.08 ng/mL in those with stage IV (p=0.002). The levels were higher at stage I (p=0.041) and markedly lower at stages III and IV than those of controls (p=0.005 and p=0.001, respectively). A similar pattern was observed when IL-33 levels were analyzed by T stage; the levels were 0.39 ng/mL at T1/T2 vs. 0.08 ng/mL at T...Continue Reading

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Citations

Sep 21, 2016·Biochemical and Biophysical Research Communications·Chunhong WangWeiqing Song
May 3, 2018·International Journal of Cancer. Journal International Du Cancer·Hong-Tai TzengYi-Ching Wang
Jun 23, 2020·Oncology Letters·Michał PudereckiBarbara Marzec-Kotarska
Sep 13, 2018·International Journal of Molecular Sciences·Kristen M LarsenMaria Marjorette O Peña
Jan 7, 2017·Medical Oncology·Yujiang FangMichael B Nicholl
May 26, 2018·Journal of Cellular and Molecular Medicine·Jun-Li WangYu-Jin Tang
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Oct 28, 2019·International Journal of Molecular Sciences·Alessandro AllegraSebastiano Gangemi
Jun 25, 2019·Frontiers in Immunology·Kevin J BakerElizabeth Brint
Nov 30, 2018·Frontiers in Immunology·Claudia AfferniGiovanna Schiavoni
Sep 11, 2021·Frontiers in Immunology·Tobias BurkardHeinfried H Radeke

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