PMID: 3872100Feb 1, 1985Paper

Circulating immune complexes and rheumatoid arthritis: a comparison of different assay methods and their early predictive value for disease activity and outcome

Annals of the Rheumatic Diseases
J S ReebackF C Hay


The performance of four different assays for circulating immune complexes-the C1q solid phase method, one using protein A and one using anti-IgG, C1q PEG, and the 2% PEG method-were compared in 61 patients with early rheumatoid arthritis followed up for two years. There were weak but statistically significant correlations between the results from some of the pairs of assays, but the changes over time from any single assay did not correlate with those from any of the other assays. None of the assays predicted either future disease activity, as measured by subsequent ESR, CRP, and articular index; or functional outcome, as measured by wrist extension, Steinbocker functional capacity, and the Stanford health assessment questionnaire. It is unlikely therefore that the measurement of immune complexes is of value in predicting early outcome in patients with rheumatoid arthritis.


May 1, 1979·Arthritis and Rheumatism·R C GuptaD Ilstrup
May 1, 1979·Arthritis and Rheumatism·J T HallaR E Schrohenloher
Jan 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·C B Laurell
May 1, 1974·Arthritis and Rheumatism·N J Zvaifler
Oct 1, 1982·Arthritis and Rheumatism·P H Plotz
Jan 1, 1961·The Journal of Clinical Investigation·H G KUNKELT B TOMASI

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Jan 1, 1986·Rheumatology International·A J SilmanD Jaraquemada
Feb 1, 1992·Baillière's Clinical Rheumatology·F A Wollheim, K B Eberhardt
Sep 1, 1992·Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association·D R RameyJ F Fries
Mar 3, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ke-Qin ZengXiao-Ming Gao
Oct 1, 1994·Seminars in Arthritis and Rheumatism·I G Otterness

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