PMID: 375940May 1, 1979Paper

Circulating immune complexes in mixed connective tissue disease

Arthritis and Rheumatism
J T HallaR E Schrohenloher

Abstract

Circulating immune complexes were measured by three assays (monoclonal rheumatoid factor radioimmunoassay, C1q-binding assay, Raji cell radioassay) in sera from patients with mixed connective tissue disease. Evidence for circulating immune complexes was found by at least one method in 94% of sera. The highest frequency of positive results was noted by the Raji cell radioassay (88%). However, a significant number of patients also had immune complexes measured by the C1q-binding assay (50%) and monoclonal rheumatoid factor radioimmunoassay (45%). Further, the levels of immune complexes are measured by the Raji cell radioassay, and to a lesser extent the C1q-binding assay, correlated with disease activity and represent a potentially useful clinical tool. The pattern of reactivity in mixed connective tissue disease sera differed from rheumatoid arthritis, scleroderma, and polymyositis. This suggests that a spectrum of immune complexes is found in these rheumatic diseases and supports the concept that mixed connective tissue disease is distinct from these diseases.

References

Jan 1, 1977·The American Journal of the Medical Sciences·M HamburgerP Barland
May 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·H Metzger
Dec 1, 1956·The American Journal of Medicine·C M PLOTZ, J M SINGER

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Citations

May 1, 1979·Arthritis and Rheumatism·J T HallaR E Schrohenloher
Jan 1, 1981·Springer Seminars in Immunopathology·T J Lawley, R P Hall
Dec 1, 1984·Clinical Rheumatology·J CalderonJ Gomez-Reyno
Jul 11, 1986·Journal of Immunological Methods·N NegoroT Inoue
Oct 1, 1985·The American Journal of the Medical Sciences·K R McLeishA F Gohara
Nov 1, 1981·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D R SchultzS H Moss
May 1, 1984·Journal of the American Academy of Dermatology·K B Yancey, T J Lawley
Nov 1, 1986·Seminars in Arthritis and Rheumatism·R C KitridouS G Massry
Feb 1, 1981·The Journal of Dermatology·S Miyagawa, K Sakamoto
Jul 1, 1993·Journal of Child Neurology·W D GrafD D Sherry
Oct 1, 1982·Arthritis and Rheumatism·J R SeiboldG P Rodnan
Nov 1, 1980·Postgraduate Medicine·R C Williams
Jun 3, 2021·Rheumatology International·Pramod Prahlad ChebbiDebashish Danda
Feb 1, 1993·The American Journal of the Medical Sciences·B Mukerji, J G Hardin

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