Aug 17, 2005

Circulating inflammatory markers and risks of cardiovascular and non-cardiovascular disease

Journal of Thrombosis and Haemostasis : JTH
G Lowe

Abstract

There is current interest in the associations of circulating inflammatory markers (C-reactive protein, fibrinogen, white cell count, albumin, erythrocyte sedimentation rate, the factor VIII:von Willebrand factor complex, the tissue plasminogen activator:plasminogen activator inhibitor type 1 complex, fibrin D-dimer) not only with prognosis in acute coronary syndromes and acute stroke, but also in prediction of cardiovascular events in the general population. Recent meta-analyses of long-term prospective studies have established their associations with coronary heart disease (CHD) events, which may be cause, consequence or coincidence. These markers are also associated in epidemiologic studies of general populations with many cardiovascular risk factors (which may confound their associations with CHD risk), and also with asymptomatic arterial disease (of which they be consequences: 'reverse causality'). The causality of their associations with cardiovascular events is questioned by their lack of specificity for risk of cardiovascular events; and by the lack of association of their functional genotypes with CHD in 'Mendelian randomized trials'. Hence, proof of causality awaits testing in randomized-controlled trials of long-term ...Continue Reading

Mentioned in this Paper

C-reactive Protein Measurement
Fibrinogen
Fibrinogen Assay
Erythrocyte Sedimentation Rate Measurement
Cerebral Arterial Diseases
F8 gene
Etiology
Coronary Arteriosclerosis
Cardiovascular Diseases
Acute Cerebrovascular Accidents

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