PMID: 7522843Oct 1, 1994Paper

Circulating insulin-like growth factor II/mannose-6-phosphate receptor and insulin-like growth factor binding proteins in fetal sheep plasma are regulated by glucose and insulin

European Journal of Endocrinology
B W GallaherB H Breier

Abstract

We have reported previously that levels of insulin-like growth factor I (IGF-I) and IGF-II in fetal sheep plasma decrease with maternal starvation and increase following an infusion of glucose to the starved fetus, while a fetal infusion of insulin elevates UGF-I alone. We now report the changes in the circulating IGF-II/M6P receptor and plasma IGF binding proteins (IGFBPs), as measured by western blotting and ligand blotting, respectively, in fetus and mother during this study. In fetal plasma, the circulating IGF-II/mannose-6-phosphate (M6P) receptor, IGFBP-3 and IGFBP-4 were reduced during starvation. While circulating IGF-II/M6P receptor and IGFBP-4 levels were increased following the fetal insulin or glucose infusion, IGFBP-3 was unchanged and increased only after 48 h of maternal refeeding. Both IGFBP-1 and IGFBP-2 increased with starvation but while IGFBP-1 levels returned to control values following both insulin and glucose infusion, levels of IGFBP-2 were not reduced significantly by either infusion or by refeeding. In maternal plasma, levels of IGFBP-3 and IGFBP-4 decreased while IGFBP-1 and IGFBP-2 increased after 48 h of starvation. Levels of each IGFBP were unaltered following the fetal infusions but returned to va...Continue Reading

Citations

Jan 1, 1995·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·G Mathé
May 4, 2013·Seminars in Fetal & Neonatal Medicine·F H BloomfieldJ E Harding
Sep 18, 2003·Placenta·Abigail L Fowden
Aug 30, 2000·Molecular and Cellular Endocrinology·P Monget, C Bondy
Jul 1, 1997·Acta Paediatrica. Supplement·P D Gluckman, J E Harding
Feb 28, 2002·Pediatric Research·Frank H BloomfieldJane E Harding
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·S I TazukeL C Giudice
Apr 1, 1994·Acta Paediatrica. Supplement·P D Gluckman, J E Harding
Mar 13, 2009·Organogenesis·Melanie A HyattMichael E Symonds
Jul 1, 1996·Journal of Pediatric Endocrinology & Metabolism : JPEM·F ColonnaL Radillo
Jun 1, 1996·Nutrition Reviews·S Langley-Evans, A Jackson
May 6, 2003·The Journal of Nutrition·Peter D Gluckman, Catherine S Pinal
Jan 1, 1997·Life Sciences·S C Langley-Evans

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