PMID: 9425505Jan 1, 1997Paper

Circulating insulin-like growth factor system changes in women with acute estrogen deficiency induced by GnRH agonist

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
S PoiraudeauM Corvol

Abstract

This prospective longitudinal study was undertaken to examine the short-term effects (6 months) of estrogen withdrawal on the circulating IGF system. A series of 40 patients suffering from endometriosis was studied before and after a 6-month treatment period with gonadotrophin releasing hormone (GnRH) agonist and calcium, with or without nasal salmon calcitonin. The plasma concentrations of insulin-like growth factor I (IGF-I) and insulin-like growth factor II (IGF-II) were measured by radioimmunoassay and radioreceptor assay respectively. Plasma IGF binding proteins (IGFBPs) were quantified and characterized by ligand blot and immunoblot. In all patients, a secondary hypoestrogenism was observed, including a 4% decrease in lumbar bone mineral density (L-BMD). The plasma IGF-I and IGF-II concentrations increased after treatment (24%, p < 0.0005 and 40%, p < 0.004 respectively), with no significant difference between the treatment groups. There was a positive correlation between plasma IGF-I (but not IGF-II) changes and changes in urinary deoxypyridinoline (r = 0.32, p < 0.05), urinary C telopeptide of type 1 collagen (r = 0.33, p < 0.04) and total plasma alkaline phosphatases (r = 0.33, p < 0.04). No correlation was found betwe...Continue Reading

Citations

Feb 15, 2001·Fertility and Sterility·H J CardimJ A Pinotti
Oct 31, 2001·Maturitas·C PosaciA Onvural
Apr 17, 2002·Maturitas·R Druckmann, U D Rohr
Jul 31, 2003·Journal of Biomedical Materials Research. Part a·Elsie DamienPeter A Revell
May 9, 2007·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Bruno MozzanegaSaula Vigili de Kreutzenberg

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