PMID: 7543554Jun 1, 1995Paper

Circulating insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs) and tissue mRNA levels of IGFBP-2 and IGFBP-4 in the ovine fetus

The Journal of Endocrinology
J M CarrJ C Wallace

Abstract

The IGF-binding proteins (IGFBPs) are a family of at least six structurally related proteins, which bind the IGFs and modulate their actions, including the regulation of pre- and postnatal growth. In this study we have examined the relationship between circulating and tissue mRNA levels of IGFBPs and related this to circulating IGFs in the fetal sheep over the gestational period when rapid growth and development occurs. Circulating IGFBP-2, as measured by Western ligand blot (WLB), increases between early and mid gestation, remains high, then declines throughout late gestation (P = 0.0002). Circulating IGFBP-3 increases throughout gestation, as measured by WLB or RIA (P = 0.04 and P = 0.0001 respectively), as does circulating IGFBP-4 (P = 0.004). These ontogenic changes in circulating IGFBPs-2 and -4 are paralleled by changes in liver mRNA for these proteins and, for IGFBP-2, by those in kidney IGFBP-2 mRNA also. This suggests that liver and kidney may be the primary contributors to circulating IGFBP-2 and the liver to circulating IGFBP-4, IGFBP-2 mRNA is present in the heart and lung in early gestation but barely detectable in these tissues after approximately 60 days gestation. IGFBP-4 mRNA is also present in the heart in ear...Continue Reading

Citations

Sep 18, 2003·Placenta·Abigail L Fowden
Nov 5, 1997·Molecular and Cellular Endocrinology·D J Lindenbergh-KortleveS L Drop
Jun 4, 2011·Reproduction, Fertility, and Development·Ellen C JensenMaureen Keller-Wood
May 22, 2008·American Journal of Physiology. Endocrinology and Metabolism·Kathryn L GatfordDeborah M Sloboda
Jan 31, 2006·BMC Developmental Biology·Mark R Corkins, Michael J Fillenwarth
Feb 12, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Gina C MickeVivienne E A Perry
Feb 15, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jaime A DuffieldI Caroline McMillen
Apr 30, 2019·Reproduction, Fertility, and Development·Jennifer A HetzMarilyn B Renfree
Mar 25, 2006·Endocrinology·Amanda N Sferruzzi-PerriClaire T Roberts
Sep 8, 2007·Canadian Journal of Physiology and Pharmacology·Amanda C BoyceEugenie R Lumbers
Apr 6, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·G A BraemsF Possmayer
Sep 28, 2006·American Journal of Physiology. Endocrinology and Metabolism·Kathryn L GatfordJulie A Owens
Jun 19, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A C MarshE R Lumbers

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