Circulating Interferon-Inducible Protein IFI16 Correlates With Clinical and Serological Features in Rheumatoid Arthritis

Arthritis Care & Research
Alessia AlunnoRoberto Gerli

Abstract

The interferon-inducible protein 16 (IFI16) has been detected in sera from patients with autoimmune/inflammatory diseases, but not in healthy subjects. This leaking leads to loss of tolerance toward this self-protein and the development of autoantibodies. In this study, clinical significance of both IFI16 protein and anti-IFI16 antibodies in rheumatoid arthritis (RA) was investigated. IFI16 protein and anti-IFI16 antibody levels were assessed by enzyme-linked immunosorbent assay in serum samples from 154 RA patients and 182 healthy controls, and in synovial fluid (SF) samples from 21 RA patients and 25 patients with osteoarthritis (OA). Mean serum levels for both IFI16 and anti-IFI16 antibodies were higher in RA patients than in healthy controls, with a direct correlation between IFI16 concentration and anti-IFI16 antibody titer. The majority of RA patients with detectable circulating IFI16 protein were also positive for rheumatoid factor (RF)/anti-cyclic citrullinated peptide antibody (anti-CCP). The latter group was found to be positive for anti-IFI16 antibodies as well. The mean SF concentrations of both IFI16 protein and anti-IFI16 antibodies were higher in RA patients when compared with control OA patients. Interestingly, ...Continue Reading

References

Aug 20, 2005·Immunology·Kazuo UchidaKen-Ichi Kozaki
Mar 20, 2010·Autoimmunity·Silvano SozzaniAngela Tincani
May 1, 2012·Arthritis Research & Therapy·Hennie G RatermanAlexandre E Voskuyl
Aug 22, 2012·Nature Reviews. Rheumatology·William P Arend, Gary S Firestein
Dec 20, 2012·Current Opinion in Rheumatology·Lars Rönnblom, Maija-Leena Eloranta
Feb 26, 2013·Annals of the Rheumatic Diseases·Joyce LübbersCornelis L Verweij
May 17, 2014·Rheumatology·Elizabeth PerryDavid Hutchinson
Jun 8, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mary K Crow
Jul 30, 2014·Nature Reviews. Rheumatology·Anca I CatrinaLars Klareskog
Dec 4, 2014·Cytokine & Growth Factor Reviews·Mandar BawadekarSanto Landolfo

❮ Previous
Next ❯

Citations

Mar 24, 2018·Cellular & Molecular Immunology·Carlo SelmiM Eric Gershwin
Dec 15, 2017·BioMed Research International·Alessia AlunnoFrancesco Carubbi
Oct 2, 2019·Clinical and Experimental Immunology·M De AndreaC Selmi
Jan 18, 2018·International Journal of Rheumatic Diseases·Rongbin LiJianwei Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.