Circulating Irisin Level and Thyroid Dysfunction: A Systematic Review and Meta-Analysis.

BioMed Research International
Dan ShanYayi Hu

Abstract

Both thyroid hormones and irisin have profound influences on the metabolism of the human body. Based on their similarities, several studies have been conducted to explore changes in irisin levels in patients with hypothyroidism and hyperthyroidism. This study was conducted in accordance with the PRISMA statement and the MOOSE reporting guideline. Based on a preregistered protocol (PROSPERO-CRD42019138430), a comprehensive search of eight databases was performed from inception to April 2020. Studies with original data collected from patients with thyroid dysfunction were included. Subgroup analysis was performed based on the different types of clinical manifestations and patient characteristics. The quality of each study and the presence of publication bias were assessed by the Newcastle-Ottawa score (NOS) and funnel plot with Egger's test, respectively. A total of 11 studies with 1210 participants were included. Ten studies were identified as high-quality studies. Pooled analysis indicated decreased irisin levels in patients with hypothyroidism (MD -10.37, 95% CI -17.81 to -2.93). Subgroup analysis revealed an even lower level of irisin in patients with clinical-type hypothyroidism (MD -17.03, 95% CI -30.58 to -3.49) and hypoth...Continue Reading

References

Feb 12, 2002·The Journal of Clinical Endocrinology and Metabolism·Joseph G HollowellLewis E Braverman
Dec 19, 2002·Thyroid : Official Journal of the American Thyroid Association·Mark P J Vanderpump, W Michael G Tunbridge
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Apr 21, 2005·BMC Medical Research Methodology·Stela Pudar HozoIztok Hozo
Feb 23, 2010·International Journal of Surgery·David MoherUNKNOWN PRISMA Group
Dec 24, 2011·Drugs·Deepak Khandelwal, Nikhil Tandon
Sep 8, 2012·Thyroid : Official Journal of the American Thyroid Association·Jeffrey R GarberUNKNOWN American Association Of Clinical Endocrinologists And American Thyroid Association Taskforce On Hypothyroidism In Adults
Jan 16, 2014·The Journal of Clinical Endocrinology and Metabolism·Ane Garmendia MadariagaJuan C Galofré
Jan 18, 2014·Autoimmunity Reviews·P CaturegliN R Rose
May 2, 2014·The Journal of Clinical Endocrinology and Metabolism·Hae Yoon ChoiKyung Mook Choi
Aug 8, 2014·Peptides·Marek RuchalaEwelina Szczepanek-Parulska
Oct 8, 2014·Clinical Endocrinology·A B CrujeirasF F Casanueva
Feb 28, 2015·Metabolism: Clinical and Experimental·Doaa M SamyRasha A Nassra
May 9, 2015·Diabetes/metabolism Research and Reviews·Ning ChenShaohui Jia
Jul 23, 2015·Archives of Endocrinology and Metabolism·İhsan AteşFatma Meriç Yılmaz
Jan 23, 2016·Current Problems in Cardiology·Irwin Klein, Sara Danzi
Feb 18, 2016·Endokrynologia Polska·Ariadna Zybek-KocikMarek Ruchała
Apr 4, 2016·Lancet·Simone De LeoLewis E Braverman
May 14, 2016·Metabolism: Clinical and Experimental·Shanhu QiuUwe Schumann
Jun 9, 2016·Thyroid : Official Journal of the American Thyroid Association·Grigorios PanagiotouChristos S Mantzoros
Jun 15, 2016·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·X-L DuZ-T Lv
Aug 16, 2016·Thyroid : Official Journal of the American Thyroid Association·Douglas S RossMartin A Walter
Dec 18, 2016·Archives of Medical Research·Mehmet Muhittin YalcinFusun Balos Toruner
Jan 19, 2017·Hormone Molecular Biology and Clinical Investigation·Thereza Cristina Lonzetti BargutCarlos Alberto Mandarim-de-Lacerda
Mar 16, 2017·Clinical Endocrinology·Asha Hesarghatta Shyamasunder, Prakash Abraham
Mar 25, 2017·Lancet·Layal ChakerRobin P Peeters
Apr 25, 2017·Annals of the New York Academy of Sciences·Graziana ColaianniMaria Grano
Nov 22, 2017·Minerva endocrinologica·Wenwen GuoXia Wang
Nov 22, 2017·Minerva endocrinologica·Silvia I BrigantiAndrea Palermo
Nov 25, 2017·Endocrine·Stergios A PolyzosChristos S Mantzoros
Nov 29, 2017·Hormone Molecular Biology and Clinical Investigation·Emine AticiEsma Menevse
Dec 3, 2017·Clinical Endocrinology·Ariadna Zybek-KocikMarek Ruchała
Dec 9, 2017·Reproductive Biomedicine Online·Xue CaiUwe Schumann
Feb 7, 2018·Bratislavské lekárske listy·E AticiR Mogulkoc
Feb 8, 2018·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hassan AskariMohammad Abdollahi
Apr 3, 2018·Peptides·Mohamed Omer MahgoubErnest Adeghate
May 20, 2018·Journal of Endocrinological Investigation·Z A UcS Gullu
Jun 5, 2018·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Mustafa ŞahinAli Rıza Uysal
Feb 7, 2019·The Journal of International Medical Research·Ning YangGuang Wang
Mar 14, 2019·Archives of Endocrinology and Metabolism·Hamiyet Yilmaz YasarErdem Yasar
Aug 14, 2019·Menopause : the Journal of the North American Menopause Society·Kunyan ZhouDan Shan
Nov 7, 2019·Menopause : the Journal of the North American Menopause Society·Kunyan ZhouDan Shan
Feb 7, 2020·Molecular and Cellular Endocrinology·Miriane de OliveiraCélia Regina Nogueira

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

R
metafor

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.