PMID: 9181253May 1, 1997Paper

Circulating kallikreins during sodium chloride infusion in normal and hypertensive humans

Blood Pressure
K P Ohman, B E Karlberg

Abstract

The stimuli generating kinins participating in blood pressure, volume and sodium homeostasis and their origin are not fully known. We studied the effects of a combined sodium and volume load on circulating plasma and tissue kallikreins. Normal saline (2000 ml) was infused over 4 h in 14 subjects with primary hypertension and 15 age- and sex-matched normotensive control subjects. The infusion increased blood pressure slightly in both groups. Plasma prekallikrein levels fell in both groups (normotensives: 98 +/- 4 to 87 +/- 5%, p = 0.002; hypertensives: 106 +/- 5 to 94 +/- 6%, p = 0.003), but more rapidly in normotensives. Circulating tissue kallikrein did not change significantly in the normotensive group but was reduced in the hypertensive group. Sodium excretion during the infusion correlated negatively with changes in plasma prekallikrein and positively with plasma levels of tissue kallikrein in the normotensive group only. Urinary tissue kallikrein excretion during the infusion increased significantly only in the normotensive group. The levels or changes of circulating prekallikrein and tissue kallikrein were not related to the levels or changes in blood pressure in any of the groups. In the hypertensive group there was a ne...Continue Reading

References

Mar 15, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·A M KappelgaardJ Giese
Nov 13, 1971·Lancet·H S MargolisA Sjoerdsma
Apr 1, 1974·The Journal of Clinical Endocrinology and Metabolism·J K McKenzie, J A Clements
Jun 11, 1993·Biochimica Et Biophysica Acta·M M KhanT Kambara

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