Circulating leptin in normal children and during the dynamic phase of juvenile obesity: relation to body fatness, energy metabolism, caloric intake, and sexual dimorphism

Diabetes
N LahlouP F Bougnères

Abstract

In 112 obese compared with 42 lean children, we found that serum leptin is elevated early in the evolution of childhood-onset obesity (28.4 +/- 1.4 vs. 4.5 +/- 0.4 ng/ml in lean children, P < 0.0001) and correlates with adiposity. Obese children also had higher serum leptin normalized to fat mass. Despite high serum leptin, obese children ingested 2-3 times more calories than did lean control subjects (P < 0.0001) and gained weight rapidly (10.2 +/- 0.3 vs. 2.9 +/- 0.1 kg/year in control subjects, P < 0.0001). Girls had higher leptin levels than did boys, in obese as well as in nonobese children, and showed a closer correlation between adiposity and serum leptin. Elevation of serum leptin was comparable before and after puberty in obese boys, but puberty further increased leptin levels in obese girls (36 +/- 3 ng/ml), resulting in a clear sexual dimorphism with pubertal obese boys (22 +/- 5 ng/ml, P < 0.005). In conclusion, increased serum leptin reflects but does not halt fat deposition in childhood obesity. After normalization to body adiposity, leptin was found to be increased independently by obesity status, female sex, and female sexual maturation.

Citations

May 12, 2005·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·R ReynaudG Simonin
Jan 5, 2002·Steroids·Darrell W BrannClint D Buchanan
Feb 26, 2000·European Journal of Obstetrics, Gynecology, and Reproductive Biology·C SchubringW Kiess
Apr 12, 2000·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·A VerrottiF Chiarelli
Sep 10, 2003·Best Practice & Research. Clinical Endocrinology & Metabolism·S BaudlerJ C Brüning
Apr 15, 2003·The Proceedings of the Nutrition Society·John R SpeakmanJulian G Mercer
May 24, 2011·International Journal of Pediatric Endocrinology·Jill K HamiltonDenis Daneman
Dec 30, 1999·Journal of Pediatric Endocrinology & Metabolism : JPEM·O D WolthersC Skjaerbaek
Dec 30, 1999·Journal of Pediatric Endocrinology & Metabolism : JPEM·E E ReitererM H Borkenstein
Mar 7, 2000·Journal of Pediatric Endocrinology & Metabolism : JPEM·K DanadianS Arslanian
Sep 2, 2000·Journal of Pediatric Endocrinology & Metabolism : JPEM·W KiessJ Kratzsch
May 10, 2000·Journal of Pediatric Endocrinology & Metabolism : JPEM·K M SudiM H Borkenstein
Oct 28, 2004·Journal of Pediatric Endocrinology & Metabolism : JPEM·Merlin G ButlerZohreh Talebizadeh
Apr 9, 2005·Journal of Pediatric Endocrinology & Metabolism : JPEM·Zehra AycanAysun Bideci
Aug 5, 2006·Journal of Pediatric Endocrinology & Metabolism : JPEM·Takeshi MatsuyamaNoriaki Nakaya
May 18, 2005·Sports Medicine·Katie WattsDaniel Green
Apr 10, 1999·Clinical Endocrinology·C S Mantzoros, S J Moschos
Nov 21, 1998·European Journal of Clinical Investigation·H A KoistinenV A Koivisto
Aug 17, 2006·Pediatrics International : Official Journal of the Japan Pediatric Society·Mehmet Emre AtabekOzgur Pirgon
Sep 29, 2006·Clinical Biochemistry·Allison A VennerPatricia K Doyle-Baker
Dec 28, 1999·Endocrinology and Metabolism Clinics of North America·J N Roemmich, A D Rogol
Sep 1, 2000·Journal of Pediatric Endocrinology & Metabolism : JPEM·K SudiM H Borkenstein
Nov 24, 2006·Endocrine Reviews·Sadaf Farooqi, Stephen O'Rahilly
Aug 24, 1999·Endocrine Reviews·L PoretskyL C Giudice
Apr 29, 1998·The Journal of Clinical Endocrinology and Metabolism·M R PalmertP A Boepple
Nov 14, 1998·The Journal of Clinical Endocrinology and Metabolism·J LicinioP W Gold
Jul 21, 2000·The Journal of Clinical Endocrinology and Metabolism·M B HorlickR L Leibel
Sep 5, 2001·American Journal of Human Biology : the Official Journal of the Human Biology Council·Karl Michael SudiMartin Helmuth Borkenstein
Feb 17, 2007·American Journal of Medical Genetics. Part a·Merlin G Butler, Douglas C Bittel
Feb 3, 2000·Critical Reviews in Clinical Laboratory Sciences·J Himms-Hagen
Apr 5, 2002·Biological Research for Nursing·J S HarrellS Deng
Aug 24, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S BlancC Gharib
Sep 5, 2001·American Journal of Human Biology : the Official Journal of the Human Biology Council·James N. Roemmich, Alan D. Rogol
May 9, 1998·Appetite·J L JoannicB Guy-Grand

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.