Circulating leptin level in rheumatoid arthritis and its correlation with disease activity: a meta-analysis

Zeitschrift für Rheumatologie
Y H Lee, S-C Bae

Abstract

This study aimed to evaluate the relationship between the circulating serum leptin level and rheumatoid arthritis (RA) and to establish a correlation between serum leptin levels and RA activity. We searched the PUBMED, EMBASE, and Cochrane databases. A meta-analysis was performed, comparing the serum/plasma leptin levels in patients with RA and healthy controls. Correlation coefficients between serum leptin level and either disease activity score 28 (DAS28) or C‑reactive protein (CRP) in RA patients were also examined. Thirteen studies with a total of 648 RA patients and 426 controls were included in this meta-analysis. Circulating leptin level was significantly higher in the RA group than in the control group (SMD = 1.056, 95 % CI = 0.647-1.465, p = 4.2 × 10(-7)). In addition, stratification by ethnicity showed a significantly elevated leptin level in the RA group in Caucasian, Turkish, and Arab populations (SMD = 0.813, 95 % CI = 0.137-1.490, p = 0.018, SMD = 0.981, 95 % CI = 0.307-1.655, p = 0.004, and SMD = 1.469, 95 % CI = 0.443-2.495, p = 0.005 respectively). A meta-analysis of correlation coefficients showed a small but significantly positive correlation between the circulating leptin level and either DAS28 (correlation ...Continue Reading

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Citations

Feb 17, 2017·International Journal of Rheumatic Diseases·Young Ho Lee, Sang-Cheol Bae
Mar 29, 2019·International Journal of Molecular Sciences·Iona J MᵃᶜDonaldChih-Hsin Tang
Jan 19, 2019·Advances in Rheumatology·Elis Carolina de Souza FatelIsaias Dichi
Dec 26, 2018·Journal of Immunology Research·Piero RuscittiRoberto Giacomelli
Aug 25, 2019·International Journal of Molecular Sciences·Mar CarriónElena Neumann
Nov 5, 2017·Clinical Rheumatology·José Antonio De Jesús Batún-GarridoIsela Esther Juárez-Rojop
Jun 19, 2018·Frontiers in Physiology·Vera FranciscoOreste Gualillo
Oct 22, 2020·BioMed Research International·Sha-Sha TaoHai-Feng Pan
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Aug 8, 2021·Immunological Medicine·Haruka Tsuchiya, Keishi Fujio
Aug 12, 2021·Translational Research : the Journal of Laboratory and Clinical Medicine·Sara CheleschiAntonella Fioravanti

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